Drug Interactions in Infectious Diseases

Author: Stephen C. Piscitelli
Published: October 2000
Publisher: Humana Press
ISBN: 0896037509
Hardcover Book
Number of Pages: 372

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The book contains black-and-white illustrations.Leading experts in antimicrobial pharmacology comprehensively review and summarize, for rapid access, important drug interactions that occur in the treatment of infectious diseases. The authors explain the mechanisms of drug, drug and drug, and food interactions, examine their clinical significance and consequences, and detail practical clinical approaches to their management. Comprehensive and highly practical, this book offers healthcare professionals treating infectious diseases a comprehensive source of quickly accessible information about drug interaction problems, their mechanisms of action, and the best strategies for their management in busy patient care. This book is a comprehensive review of drug interactions involving common anti-infective agents. The purpose is to provide a thorough understanding of these drug interactions, which is a worthy objective. The editors also discuss in detail the strategies a practitioner should consider to avoid adverse drug interactions. They have done a fine job in achieving their objectives. This is useful for practitioners prescribing anti-infective agents, primary care providers, and infectious disease specialists, but is not limited to these. The editors state it will be a valuable resource to the clinician, educator, and researcher. The editors and contributors exhibit their authority and expertise in the subject matter with their well-written chapters. There is a detailed description on mechanisms of drug interactions in the initial chapters which is extremely valuable to our thorough understanding of drug interactions. There are well organized chapters based on the class of the anti-infective agents. The case studies described in some chapters help in illustrating the importance of the drug interactions in practice. More tables in each chapter would have contributed to making this an easy to use reference . This is a valuable text for all practitioners involved in using anti-infective agents, as contributors provide insight into the very important issue of drug interactions. This extensive review may fail to hold the attention of other practitioners. The complicated subject of drug interactions involving HIV medications is made comprehensible and interesting with the case studies. Specialists in antimicrobial pharmacology review and summarize important drug interactions that occur in the treatment of infectious diseases. They explain the mechanisms of interactions between different drugs and between drugs and food, examine their clinical significance and consequences, and detail practical clinical approaches to managing them. Chapters also focus on HIV/AIDS and tuberculosis and on quinolones, beta-lactim antibiotics, antifungal agents, and miscellaneous antibiotics. The treatment is designed as a quick daily reference for health care professionals who treat infectious diseases. Piscitelli, Stephen C., PharmD (National Institutes of Health); Rodvold, Keith A., PharmD (Univ of Illinois at Chicago)

Table of Contents
Foreword
Preface
Contributors
1 Introduction to Drug Interactions 1
2 Mechanisms of Drug Interactions 13
3 Drug Interactions with Antiretrovirals for HIV Infection 39
4 AIDS/HIV: Drugs for Opportunistic Infections 61
5 Drugs for Tuberculosis 109
6 Quinolones 121
7 Beta-Lactam Antibiotics 151
8 Antifungal Agents 185
9 Miscellaneous Antibiotics 219
10 Drug-Food Interactions 249
11 Drug-Cytokine Interactions 287
12 Circumventing Drug Interactions 311
13 Design and Data Analysis of Drug Interactions Studies 333
Index 353

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