Cytokines and Chemokines in Infectious Diseases Handbook (Infectious Disease Series)

Author: Malak Kotb
Published: September 2002
Publisher: Humana Press
ISBN: 0896039080
Hardcover Book
Number of Pages: 436

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Recent years have witnessed rapid growth in new information on the crucial role played by cytokines and chemokines in human disease, as well as on the exciting possibilities they offer for developing novel therapies and for optimizing vaccine performance. In the Cytokines and Chemokines in Infectious Diseases Handbook, international leaders in the field comprehensively review what is known about the responses of cytokines and chemokines to a variety of human infectious diseases, including gram-negative and gram-positive infections, listeriosis, mycobacterial infections, lyme arthritis, pneumonia, fungal infections, HIV, leishmaniasis, and sepsis. The authors demonstrate the different cytokine and chemokine production profiles in response to a wide range of pathogens and the importance of host genetic factors in determining the type and magnitude of responses to a given microorganism. They also critically evaluate the use of cytokines and anticytokines in the treatment of infectious diseases and show how knowledge of cytokine pleiotropic effects, redundancy, and the complexity of the cytokine network has led to better design and better outcomes in cytokine-based therapies for specific infections. The book also offers important information for those working in biodefense research through its illustration of the role of cytokines and chemokines in modulating host-pathogen interactions and vaccine responses. Comprehensive and cutting-edge, the Cytokines and Chemokines in Infectious Diseases Handbook summarizes all the new scientific and clinical discoveries essential to understanding the importance of cytokines and chemokines in human infectious diseases, and demonstrates how best to utilize their unique properties in the design and development of effective new therapeutic agents.

This work reviews what is known about the responses of cytokines and chemokines to a variety of human infectious diseases, and looks at their potential for optimizing vaccine performance. Chapters on diseases such as mycobacterial infections, lyme arthritis, HIV, and sepsis demonstrate cytokine and chemokine production profiles and discuss the importance of host genetic factors in determining type and magnitude of responses to a microorganism. Kotb is affiliated with the University of Tennessee VA Medical Center. Calandra is affiliated with the Centre Hospital Universitaire Vaudois, Switzerland.

Table of Contents:

Preface
List of Contributors
Introduction: Cytokine Biology Relevant to Infectious Diseases 1
1 Leptin: Its Role in Immunomodulation and Susceptibility to Infection 9
2 Cytokine Gene Polymorphism and Host Susceptibility to Infection 23
3 Proinflammatory and Anti-Inflammatory Cytokines as Mediators of Gram-Negative Sepsis 33
4 Host Response to Pathogenic Bacteria at Mucosal Sites 59
5 Macrophage Migration Inhibitory Factor as a Cytokine of Innate Immunity 65
6 Cytokine Patterns in Severe Invasive Group A Streptococcal Infections 77
7 Superantigens and Bacterial DNA as Dytokine Inducers in Gram-Positive Sepsis 93
8 Cytokines and Chemokines in Listeriosis 109
9 Regulation of Cytokines and Chemokines in Human Mycobacterium tuberculosis Infection 123
10 Cytokines and Chemokines in Protective and Inflammatory Responses to Infection with Nontuberculous Mycobacteria 133
11 Human Interleikin-12 - Interferon-[gamma] Axis in Protective Immunity to Mycobacteria 151
12 Role of Th1 Cytokines in Host Defenses Against Mycobacterium leprae 163
13 Possible Role of Molecular Mimicry in Lyme Arthritis 189
14 Cytokine Responses in Patients with Pneumonia 201
15 Cytokines and the Host Defense Against Aspergillus fumigatus 215
16 Cytokines of Innate and Adaptive Immunity to Candida albicans 227
17 Th1 and Th2 Cytokines in Leishmaniasis 245
18 Cytokines in the Regulation of Innate and Adaptive Immunity to Toxoplasma gondii 259
19 Viroceptors: Virus-Encoded Receptors for Cytokines and Chemokines 285
20 Chemokines and Chemokine Receptors in HIV Infection 301
21 Cytokines in Viral Hepatitis 313
22 Interferon-[gamma] in the Treatment of Infectious Diseases 331
23 Interleukin-2 for the Treatment of HIV Infection 345
24 Clinical Application of G-CSF and GM-CSF in the Treatment of Infectious Diseases 361
25 Anticytokine Therapies in Patients with Severe Sepsis and Septic Shock 381
26 Intravenous Immunoglobulin Adjunctive Therapy in Patients with Streptococcal Toxic Shock Syndrome and Necrotizing Fasciitis 409
Index 425

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