Immunosuppressant Analogs in Neuroprotection

Author: Cesario V. Borlongan
Published: November 2002
ISBN: 0896039447
Hardcover Book
Number of Pages: 416

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Neurological specialists from around the world report on clinical evidence that immunophilins and structurally similar ligands given to patients who have received organ or neural transplants, possess neurotrophic and neuroprotective properties in addition to their immuno-suppressive effects, and thus may promote graft survival and function as well as inhibiting graft rejection. Citing research on animals with neurological disorders, they discuss immuno-suppressants and Parkinson's Disease, other age- related diseases, stroke, traumatic brain injury, spinal cord injury, sciatic nerve injury, and other disorders of the central nervous system.

Table of Contents:

Foreword
Preface
Contributors
Pt. I Immunosuppressants, Neurologic Disorders, and Neuroprotection
1 Introduction: Immunosuppressants as Neuroprotective Agents 3
Pt. II Immunosuppressants and Parkinson's Disease
2 Cyclosporin-Mediated Amelioration of Degeneration of Dopaminergic Neurons in Experimental Models of Parkinsonism 35
3 Immunophilin Ligands and Dopamine Neurons: Specific Effects in Culture and In Vivo 49
4 Effects of Neuroimmunophilin Ligands on Parkinson's Disease and Cognition 67
5 Improved Survival of Grafted Dopamine Neurons by Calcineurin Inhibitors 93
6 Possible Mechanisms Underlying the Protective Action of Immunosuppressants Against Parkinson's Disease: The Mitochondrial Permeability Transition Pore Hypothesis 105
Pt. III Immunosuppressants and Other Age-Related Disorders
7 Immunosuppressants and Alzheimer's Disease 141
8 Cyclosporin A Protects Striatal Neurons from Mitochondrial Dysfunction: Implications for Huntington's Disease 159
Pt. IV Immunosuppressants, Stroke, and Traumatic Brain Injury
9 Cyclosporin A Protects Mitochondria in an In Vitro Model of Hypoxia/Reperfusion Injury 177
10 Protective Effect of Cyclosporin A on Glial Activation and White Matter Alterations Induced by Chronic Cerebral Hypoperfusion 193
11 Blockade of Late-Onset Reduction of Muscarinic Acetylcholine Receptors by Immunosuppressants in Forebrain Ischemia 215
12 The Role of Immunophilins in Focal Cerebral Ischemia: Evidence of Neuroprotection by FK506 231
13 Immunosuppressants in Traumatic Brain Injury 263
Pt. V Immunosuppressants and Spinal Cord Injury
14 Inhibition of Lipid Peroxidation by Cyclosporin After Spinal Cord Injury in Rats 283
15 Axonal Regeneration in Cyclosporin A-Treated Rats Submitted to Transverse Section of the Spinal Cord 299
Pt. VI Immunosuppressants and Sciatic Nerve Injury
16 Neuroimmunophilin Ligands Accelerate and Promote Nerve Regeneration in the Rat Peripheral Nerve and Spinal Cord: Role of the Steroid Receptor-FKBP52 Complex 317
17 Neuroimmunophilin Ligands Stimulate Recovery of Injured Sciatic Nerves 329
Pt. VII Immunosuppressants and Other Disorders of the Central Nervous System
18 Cyclosporin A Prolongs Survival of SOD1 Mutant Mice and Implicates Mitochondrial Permeability Transition in Amyotrophic Lateral Sclerosis 343
19 Psychological Effects of Cyclosporin A 361
Index 375

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