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De Broe (Department of Nephrology and Hypertension, University of Antwerp, Belgium) presents comprehensive information on all aspects of adverse effects on the kidneys by drugs, chemical substances, and radiation. A general section deals with clinical relevance, renal handling and cellular mechanisms of nephrotoxicity, and animal and cell culture models. Later chapters look at specific substances, including anti-infectious agents, anti-inflammatory drugs, and anti- cancer drugs, and describe prevention methods involving urinary biomarkers, pharmacological aspects, and drug dosages. This second edition features new material on children.

Table of Contents:

Preface
List of Contributors
1 Clinical relevance 3
2 Renal handling of drugs and xenobiotics 21
3 Pharmacovigilance 47
4 Immunologically-mediated toxin-induced renal disease 51
5 Cellular mechanisms of nephrotoxicity 65
6 Animal models for the assessment of acute renal dysfunction and injury 77
7 Renal cell culture models: contribution to the understanding of rephrotoxic mechanisms 115
8 Aminoglycosides and vancomycin 151
9 Beta-lactam antibiotics 171
10 Amphotericin B 199
11 Sulfonamides, sulfadiazine, trimethoprim-sulfamethoxazole, pentamidine pyrimethamine, dapsone, quinolones 223
12 Antiviral agents 249
13 Analgesics and 5-aminosalicylic acid 263
14 Non-steroidal anti-inflammatory drugs 279
15 Gold salts, D-penicillamine and allopurinol 307
16 Angiotensin I converting enzyme inhibitors and angiotensin II receptor antagonists 325
17 Diuretics 339
18 Anticancer drugs 353
19 Anesthetic agents 373
20 Illicit drug abuse 383
21 Calcineurinn inhibitors and sirolimus 403
22 Immunomodulators: interleukins, interferons, and the OKT3 monocolonal antibody 459
23 Radiocontrast agents 483
24 Lead nephropathy 495
25 Cadmium-induced renal effects 507
26 Mercury-induced renal effects 531
27 Hydrocarbons, silicon-containing compounds and pesticides 545
28 Lithium-induced renal effects 559
29 Aristolochic acid nephropathy after Chinese herb remedies 579
30 Balkan endemic nephropathy 587
31 Nephrotoxins in Africa 603
32 Paraphenylene diamine hair dye poisoning 611
33 Urinary biomarkers and nephrotoxicity 621
34 Pharmacological aspects of nephrotoxicity 657
35 Drug dosage in renal failure 667
List of Abbreviations 681
Index 685