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Table of Contents:

List of Contributors
Preface
1 Genomics and clinical cardiology: Hype or hope? 1
2 Salt-sensitive hypertension: Identification of downstream renal targets in the aldosterone-signaling pathway by Serial Analysis of Gene Expression (SAGE) 7
3 Cardiovascular proteomics: Effect of hypoxic conditions 21
4 Using comparative genome analysis to find interaction partners for frataxin 29
5 In vitro-in vivo gene expression analysis in atherosclerosis 43
6 Human essential hypertension: Role of the genes of the renin-aldosterone system 55
7 Gene therapy for hypertension: Future or fiction? 65
8 Hormones and signalling pathways 77
9 Endothelial changes in hypertension 83
10 Towards elucidation of genetic pathways in cardiac hypertrophy: Technique to develop microarrays 97
11 Gene expression in cardiac hypertrophy and failure: Role of G protein-coupled receptors 107
12 Little mice with big hearts. Finding the molecular basis for dilated cardiomyopathy 115
13 Cardiac hypertrophic signaling the good, the bad and the ugly 131
14 Ion channel regulation: From arrhythmias to genes to channels (to cures?) 159
15 Differential expression and functional regulation of delayed rectifier channels 167
16 Genetic polymorphisms and their role in ventricular arrhythmias 187
17 Molecular mechanisms of remodeling in human atrial fibrillation 199
18 G-protein [beta]3-subunit polymorphism and atrial fibrillation 213
19 Human stem cell gene therapy 225
20 Towards human embryonic stem cell derived cardiomyocytes 231
21 Use of mesenchymal stem cells for regeneration of cardiomyocytes and its application to the treatment of congestive heart failure 245
22 Cellular cardiac reinforcement 257
23 Appendix to session 3 hypertension: Adducin paradigm: An approach to the complexity of hypertension genetics 265
Index 273