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Table of Contents:

Contributors
Preface
Cardiomyopathies and Heart Failure: Biomolecular, Infectious and Immune Mechanisms 1
Cytokines in Cardiomyopathies and Heart Failure
1 Chemokines and Cardiovascular Diseases 17
2 Negative Regulator of Cytokine Signaling (SOCS) Genes in Inflammation 27
3 The Interleukin-6 Family of Cytokines and their Receptors of Patients with Congestive Heart Failure 39
4 Animal Model of Cardiomyopathy Due to Overexpression of TNF-[alpha] 47
Autoimmunity in Cardiomyopathies and Heart Failure
5 Myosin Autoreactive T Cells and Autoimmune Myocarditis: Lessons from the Disease Caused by Cardiac Myosin Peptide CM2 59
6 Autoimmunity in Cardiomyopathies 67
7 Anti-G-Protein Coupled Cardiac Receptor Autoantibodies in Dilated Cardiomyopathy 83
8 Clinical Significance of Circulating Cardiac Autoantibodies in Dilated Cardiomyopathy and Myocarditis 97
Mast Cell Mediators and Human Diseases: Basic Aspects
9 Development of Mast Cells: Process and Regulatory Mechanisms 111
10 Mast Cells in Experimental Myocardial Infarction 121
11 Possible Involvement of Mast Cells in the Development of Fibrosis 133
12 Human Mast Cell Chymase and 31 Amino Acid Endothelin-1 145
13 Tryptase from Human Mast Cells 159
14 Effects of the Tryptase Receptor Activating Peptide and Antibodies Against the Tryptase Receptor Par-2 on Neonatal Rat Cardiomyocytes in Culture 173
Mast Cell Mediators and Human Diseases Clinical Aspects
15 Role of Human Heart Mast Cells in Immunologic and Inflammatory Mechanisms Underlying Cardiovascular Disorders 185
16 Mast Cells in Atherosclerotic Human Coronary Arteries: Implications for Coronary Fatty Streak Formation and Plaque Erosion or Rupture 199
17 The Key Role of Mast Cells in the Evolution to Congestive Heart Failure 213
Viral Etiology of Cardiomyopathies and Heart Failure
18 Links Between Viral Infections and Heart Disease 229
19 Molecular Detection and Characterization of Human Enteroviruses 245
20 Detection and Biological Implications of Genetic Memory in Viral Quasispecies 259
21 The Group B Coxsackieviruses as Vaccines and Vectors 277
22 Detection of Important Diagnostic Markers of HCV Infection 291
Diagnosis and Treatment of Myocarditis
23 Large Animal Model of Viral Myocarditis 301
24 Hepatitis C Virus and Cardiomyopathy 325
25 Diagnosis and Treatment of Myocarditis: The Role of Adenovirus Infection in Cardiomyopathy and Heart Failure 341
26 The Natural History of Viral Myocarditis: Pathogenetic Role of Adrenergic System Dysfunction in the Development of Idiopathic Dilated Cardiomyopathy 357
27 Clinical Diagnosis of Myocarditis 373
28 Recent Advances in Giant Cell Myocarditis 389
29 Registry of Myocarditis and Heart Failure 401
Molecular and Genetic Analyses in Heart Disease
30 Molecular Etiology of Idiopathic Cardiomyopathy 415
31 Gene-Based Therapy of Long QT Syndrome 429
The Future of the Management of Cardiomyopathies and Heart Failure
32 How Does Adenosine Mediate Cardioprotection? 439
33 Protection of Cell Injury by Thioredoxin 457
34 Hematopoietic Stem Cells and Angiogenesis 469
35 Transplanting Cells for the Treatment of Cardiomyopathy 481
36 Toward an Ideal Large Animal Model of Dilated Cardiomyopathy to Study Left Ventricular Volume Reduction Surgery
37 Heart Transplantation: 35 Years of Progress 503
38 Genes of the Major Histocompability Complex Class II Influence the Phenotype of Cardiomyopathies Associated with Hepatitis C Virus Injection 515
Index 523