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Table of Contents:

Preface
Acknowledgement
Introduction and historical notes 1
1 Contribution of astrocyte glutamate release to excitotoxicity 13
2 Glutamate uptake and transporters 27
3 NMDA receptors 51
4 AMPA receptor and synaptic plasticity 65
5 Metabotropic glutamate receptors and neurodegeneration 79
6 Mechanisms of excitotoxicity and excitoprotection 103
7 Epilepsy and seizures: excitotoxicity or excitotrophicity? 137
8 Excitotoxicity in cerebral ischemia 171
9 Excitotoxicity and traumatic brain injury 189
10 Excitotoxicity in amyotrophic lateral sclerosis: selective vulnerability of motor neurons 217
11 Glutamate transmission in the pathogenesis of Parkinson's disease 229
12 Excitotoxicity in Huntington's Disease 243
13 The glutamatergic system in Alzheimer's disease brain: dysfunction associated with amyloid [beta]-peptide and oxidative stress 251
14 Neurotoxicity and prion disease 263
15 Glutamate excitotoxicity in multiple sclerosis 285
16 HIV-1 associated dementia 305
17 Markers of excitotoxicity in patients: tool for diagnosis or therapy? 317
18 Anti-excitotoxic therapies in neurological diseases: current evidences and new perspectives 339