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Contributors ix
Preface to the First Edition xvi
Preface to the Second Edition xvii
Preface to the Third Edition xviii
Tribute xix
List of Abbreviations xxi
Section 1 Scientific Basis for Hematopoietic Cell Transplantation
1 A History of Bone Marrow Transplantation 3
2 Uses and Growth of Hematopoietic Cell Transplantation 9
3 Overview of Hematopoietic Cell Transplantation Immunology 16
4 Histocompatibility 31
5 Functional Evolution of the Major Histocompatibility Complex 43
6 The Hematopoietic Microenvironment 53
7 Molecular Aspects of Stem Cell Renewal 62
8 Biology of Hematopoietic Stem and Progenitor Cells 69
9 Expansion of Hematopoietic Stem Cells 96
10 Methods for Gene Transfer: Genetic Manipulation of Hematopoietic Stem Cells 107
11 Clinical Trials of Gene Marking and Gene Therapy Using Hematopoietic Stem Cells 118
12 Pharmacological Basis for High-Dose Chemotherapy 130
13 Preparative Regimens and Modification of Regimen-Related Toxicities 158
14 Radiotherapeutic Principles of Hematopoietic Cell Transplantation 178
15 Radioimmunotherapy and Hematopoietic Cell Transplantation 198
16 Pharmacology and the Use of Immunosuppressive Agents after Hematopoietic Cell Transplantation 209
17 T-Cell Depletion to Prevent Graft-vs.-Host Disease 221
18 Documentation of Engraftment and Characterization of Chimerism Following Hematopoietic Cell Transplantation 234
19 Antibody Mediated Purging 244
20 Pharmacologic Purging of Bone Marrow 254
21 Molecular Inhibition of Gene Expression in Hematopoietic Cells 258
22 The Detection and Significance of Minimal Residual Disease 272
23 Pathology of Hematopoietic Cell Transplantation 286
24 Mechanisms of Tolerance 300
25 The Experimental Basis for Hematopoietic Cell Transplantation for Autoimmune Diseases 324
26 Murine Models for Graft-vs.-Host Disease 344
27 The Pathophysiology of Graft-vs.-Host Disease 353
28 Graft-versus-Tumor Responses 369
29 Adoptive Immunotherapy with Antigen-Specific T Cells 380
30 Autologous Graft-vs.-Host Disease 405
31 Biostatistical Methods in Hematopoietic Cell Transplantation 414
32 Outcomes Research in Hematopoietic Cell Transplantation 434
Section 2 Patient-Related Issues in Hematopoietic Cell Transplantation
33 The Evaluation and Counseling of Candidates for Hematopoietic Cell Transplantation 449
34 Clinical and Administrative Support for Hematopoietic Cell Transplant Programs 463
35 Nursing Issues in Hematopoietic Cell Transplantation 469
36 The Patient's Perspective 483
37 Ethical Issues in Hematopoietic Cell Transplantation 488
38 Psychosocial Issues in Hematopoietic Cell Transplantation 497
39 Assessment of Quality of Life in Hematopoietic Cell Transplantation Recipients 507
40 Sexuality after Hematopoietic Cell Transplantation 519
Section 3 Sources of Hematopoietic Cells for Human Transplant
41 Hematopoietic Cell Procurement, Processing and Transplantation: Regulation and Accreditation 531
42 Hematopoietic Cell Donors 538
43 Cord Blood Hematopoietic Cell Transplantation 550
44 In Utero Transplantation 565
45 Mobilization of Autologous Peripheral Blood Hematopoietic Cells for Support of High-Dose Cancer Therapy 576
46 Peripheral Blood Hematopoietic Cells for Allogeneic Transplantation 588
47 Cryopreservation of Hematopoietic Cells 599
48 Recombinant Growth Factors after Hematopoietic Cell Transplantation 613
49 Hematopoietic Cell Donor Registries 624
Section 4 Complications and Their Management
50 Graft-vs.-Host Disease 635
51 Bacterial Infections 665
52 Fungal Infections after Hematopoietic Cell Transplantation 683
53 Cytomegalovirus Infection 701
54 Herpes Simplex Virus Infections 727
55 Varicella-Zoster Virus Infections 732
56 Epstein-Barr Virus Infection 749
57 Other Viral Infections after Hematopoietic Cell Transplantation 757
58 Gastrointestinal and Hepatic Complications 769
59 Neurological Complications of Hematopoietic Cell Transplantation 811
60 Blood Group Incompatibilities and Hemolytic Complications of Hematopoietic Cell Transplantation 824
61 Principles of Transfusion Support before and after Hematopoietic Cell Transplantation 833
62 Immunological Reconstitution following Hematopoietic Cell Transplantation 853
63 Vaccination of Hematopoietic Cell Transplant Recipients 862
64 Pulmonary Complications after Hematopoietic Cell Transplantation 873
65 Nutritional Support of Hematopoietic Cell Recipients 883
66 Pain Management 894
67 Oral Complications 911
68 Growth and Development after Hematopoietic Cell Transplantation 929
69 Delayed Complications after Hematopoietic Cell Transplantation 944
70 Secondary Malignancies after Hematopoietic Cell Transplantation 962
Section 5 Allogeneic Transplantation for Acquired Diseases
71 Allogeneic Hematopoietic Cell Transplantation for Aplastic Anemia 981
72 Allogeneic Transplantation for Paroxysmal Nocturnal Hemoglobinuria 1002
73 Allogeneic Transplantation for Chronic Myeloid Leukemia 1007
74 Hematopoietic Cell Transplantation for Juvenile Myelomonocytic Leukemia 1018
75 Allogeneic Hematopoietic Cell Transplantation for Adult Patients with Acute Myeloid Leukemia 1025
76 Allogeneic Transplantation for Acute Myeloid Leukemia in Children 1040
77 Allogeneic Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia in Adults 1055
78 Allogeneic Transplantation for Acute Lymphoblastic Leukemia in Children 1067
79 Allogeneic Transplantation for Myelodysplastic and Myeloproliferative Disorders 1084
80 Allogeneic Hematopoietic Cell Transplantation for Multiple Myeloma 1096
81 Allogeneic Transplantation for Lymphoma and Chronic Lymphocytic Leukemia 1105
82 Hematopoietic Cell Transplantation from HLA Partially Matched Related Donors 1116
83 Hematopoietic Cell Transplantation from Unrelated Donors 1132
84 Management of Relapse after Allogeneic Transplantation 1150
85 Nonmyeloablative Therapy and Hematopoietic Cell Transplantation for Hematologic Disorders 1164
86 Allogeneic Hematopoietic Cell Transplantation for Solid Tumors 1177
Section 6 Autologous Transplantation for Acquired Diseases
87 Autologous and Allogeneic Hematopoietic Cell Transplantation for Hodgkin's Disease 1191
88 Autologous Hematopoietic Cell Transplantation for Non-Hodgkin's Lymphoma 1207
89 Autologous Hematopoietic Cell Transplantation for Acute Myeloid Leukemia 1221
90 Autologous Hematopoietic Cell Transplantation for Acute Lymphoblastic Leukemia 1238
91 Autologous Hematopoietic Cell Transplantation for Chronic Myeloid Leukemia 1250
92 Autologous Hematopoietic Cell Transplantation for Multiple Myeloma 1262
93 Autologous Hematopoietic Cell Transplantation for AL Amyloidosis 1283
94 Hematopoietic Cell Transplantation for Breast Cancer 1298
95 Hematopoietic Cell Transplantation in Germ Cell Tumors 1308
96 Hematopoietic Cell Transplantation in Ovarian Carcinoma 1320
97 Hematopoietic Cell Transplantation for Neuroblastoma 1333
98 Hematopoietic Cell Transplantation for Brain Tumors 1345
99 Hematopoietic Cell Transplantation for Pediatric Patients with Solid Tumors 1354
100 AIDS and Hematopoietic Transplantation: HIV Infection, AIDS, Lymphoma and Gene Therapy 1369
101 Hematopoietic Stem Cell Transplantation for Autoimmune Diseases 1385
102 Prevention and Therapy of Relapse following Autologous Hematopoietic Cell Transplantation 1394
Section 7 Allogeneic Transplantation for Inherited Disease
103 Marrow Transplantation in Thalassemia 1409
104 Hematopoietic Cell Transplantation for Sickle Cell Disease 1417
105 Hematopoietic Cell Transplantation for Immunodeficiency Diseases 1430
106 Hematopoietic Cell Transplantation for Osteopetrosis 1443
107 Hematopoietic Cell Transplantation for Storage Diseases 1455
108 Hematopoietic Cell Transplantation for Macrophage and Granulocyte Disorders 1471
109 Hematopoietic Cell Transplantation for Fanconi Anemia 1483
Section 8 The Future
110 Hematopoietic Cell Transplantation in the 21st Century 1507
Section 9 Colorplates, facing page 296
Index 1511