Antimicrobial/Anti-Infective Materials: Principles, Applications and Devices

Author: Samuel P. Sawan
Published: December 1999
Publisher: CRC Press
ISBN: 1566767946
Number of Pages: 346

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Prepared by device designers and clinicians, Antimicrobial/Anti-Infective Materials: Principles, Applications and Devices represents the best current research and practice on ways to reduce infection caused by devices inserted into the human body. This book summarizes the etiology of device-induced infections and explains current and experimental strategies for modifying components of implants, grafts, and catheters to mitigate infections. Among the strategies are coating, surface modification, controlled release, and intelligent coatings. Antimicrobial/Anti-Infective Materials: Principles, Applications and Devices also explores novel testing methods and concepts for lowering costs. This book will benefit anyone who designs, uses, and monitors anti-infective materials, as well as those who develop and apply products made from these materials. Special features Medical biomaterials specialists Medical device product developers, designers and manufacturers Surface engineers for biomaterials Clinicians and therapists who monitor device-caused infections, e.g., orthopaedic specialists Persons interested in controlled drug release Attendees at past Sawan seminars Explains the etiology of device-induced infections Covers current and experimental strategies for preparing materials to resist infection Includes novel approaches such as intelligent coatings Applicable to a wide range of medical devices Provides information on device testing Prepared by device designers and clinicians, the present text represents the best current research and practice on ways to reduce infection caused by devices inserted into the human body. It summarizes the etiology of device-induced infections andexplains current and experimental strategies for modifying components of implants, grafts, and catheters to mitigate infections. Among the strategies are coating, surface modification, controlled release, and intelligent coatings. In addition, the book explores novel testing methods and concepts for lowering costs. It will benefit anyone who designs, uses, and monitors antiinfective materials, as well as those who develop and apply products made from these materials." "Explains the etiology of device-induced infections Covers current and experimental strategies for preparing materials to resist infection Includes novel approaches such as intelligent coatings Provides information on device testing Applicable to a wide range of medical devices"

Table of Contents:

Preface
List of Contributors
1 Perspectives on Infectious Disease Challenges and Antimicrobial Answers 1
2 Infections of Intracardiac Devices 23
3 Infections in Orthopaedics 39
4 Physicochemical Basis of Bacterial Adhesion to Biomaterial Surfaces 67
5 Albumin Affinity Coatings May Prevent Foreign-Body Infections 94
6 Immobilized Biocides as an Alternative Strategy for Control of Microbial Contamination 130
7 Anti-Infective Coatings Reduce Device-Related Infections 149
8 Reduced Implant-Related Infectious Complications by Surface Modification Providing Controlled Antimicrobial Release 181
9 A Chemically Intelligent Infection-Resistant Coating 220
10 Merging of Biomedical and Textile Technologies in Order to Create Infection-Resistant Prosthetic Vascular Grafts 239
11 Aseptic Approaches and Novel Antimicrobial Catheters for Prevention of Infection of Vascular Catheters 260
12 Anti-Infective Devices in Otolaryngology: Current Applications and Future Opportunities 274
13 Laboratory Methods for Antimicrobial Susceptibility Testing 292
14 Toward Dollar Devices for Measuring Metabolic Biochemistry 317
15 Sisyphus in the Microbial World: Antimicrobial Strategies and Humanity's Health 330
Index 343

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