Stem Cell Transplantation for Hematologic Malignancies

Author: Robert J. Soiffer
Published: February 2004
Publisher: Humana Press
ISBN: 1588291804
Hardcover Book
Number of Pages: 504

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Over the past several years, fundamental notions about transplantation have changed to such a degree that even the once familiar term, bone marrow transplant, is becoming increasingly outdated. In Stem Cell Transplantation for Hematologic Malignancies, leading investigators and physicians/clinicians comprehensively survey the current state-of-the-art in hematopoietic stem cell transplantation for malignant disease. The authors focus on the indications and results of transplantation for acute leukemia, chronic myelogenous leukemia, lymphoma, multiple myeloma, and breast cancer, providing insight into the relative merits of transplant and nontransplant approaches to these disorders. Special attention is given to transplant-related complications, including the pathophysiology and clinical consequences of acute and chronic graft-vs-host disease (VGHD), delayed immune reconstitution leading to infectious complications, and organ damage to the lung and liver. Additional chapters address the sources of stem cells and the effects of graft manipulation used to eliminate residual contaminating tumor cells in autologous transplantation, or to reduce the number of T lymphocytes causing GVHD in allogenic transplantation. Also discussed are the role of donor lymphocyte infusions in the treatment and prevention of relapse after stem cell transplantation and their influence on the development of nonmyeloablative transplantation. Comprehensive and state-of-the-art, Stem Cell Transplantation for Hematologic Malignancies outlines the many exciting advances that are working toward realization today while fully explaining the process of stem cell transplantation for malignant disease.

Soiffer (Dana-Farber Cancer Institute) presents the work of leading investigators, physicians, and clinicians surveying the current state of the art in hematopoietic stem cell transplantation for malignant disease. Contributors focus on the indications and results of transplantation for acute leukemia, chronic myelogenous leukemia, lymphoma, multiple myeloma, and breast cancer, providing insight into the relative merits of transplant and nontransplant approaches to these disorders. Special attention is given to transplant-related complications, including the pathophysiology and clinical consequences of acute and chronic graft-vs-host disease, delayed immune reconstitution leading to infectious complications, and organ damage to the lung and liver. The book will be of interest to hematologists, oncologists, and researchers in stem cell transplantation.

Table of Contents:

Preface
Contributors
1 Allogeneic and Autologous Stem Cell Transplantation for Acute Leukemia and Myelodysplasia in the Adult 3
2 Hematopoietic Stem Cell Transplantation for Chronic Myelogenous Leukemia 25
3 Stem Cell Transplantation for Hodgkin's and Non-Hodgkin's Lymphomas 47
4 Autologous and Allogeneic Transplantation for Multiple Myeloma 85
5 Hematopoietic Progenitor Cell Transplantation for Breast Cancer 99
6 Pathophysiology of Acute Graft-vs.-Host Disease 135
7 Acute Graft-vs.-Host Disease 159
8 Chronic Graft-vs.-Host Disease After Transplantation 185
9 Immune Reconstitution After Allogeneic Transplantation 201
10 Infection in the Hematopoietic Stem Cell Transplant Recipient 237
11 EBV Lymphoproliferative Disease After Transplantation 259
12 Pathophysiology of Lung Injury After Hematopoietic Stem Cell Transplantation 271
13 Hepatic Veno-Occlusive Disease 297
14 Quality-of-Life Issues Posttransplantation 315
15 Stem Cell Sources: Peripheral Blood Stem Cells and Bone Marrow for Allogeneic Transplantation 337
16 Allogeneic Unrelated Donor Blood and Marrow Transplantation 357
17 Haploidentical Stem Cell Transplantation 373
18 Umbilical Cord Hematopoietic Stem Cell Transplantation 391
19 Tumor Contamination of Stem Cell Products: The Role of Purging 417
20 T-Cell Depletion to Prevent Graft-vs.-Host Disease 431
21 Donor Lymphocyte Infusions: Clinical Applications and the Graft-vs.-Leukemia Effect 453
22 Nonmyeloablative Transplantation 469
Index 483

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