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Table of Contents:

Foreword
Foreword
Foreword
Preface
Color Plates
Contributors
1 Selecting the Right Targets for Cancer Therapy 3
2 Clinical Importance of Prognostic Factors: Moving from Scientifically Interesting to Clinically Useful 51
3 Genetic Markers in Sporadic Tumors 73
4 Genetic Markers in Breast Tumors with Hereditary Predisposition 151
5 Cellular and Tissue Markers in Solid Tumors 181
6 Molecular and Pathologic Characterization of Human Tumors 215
7 Circulating Tumor Markers 233
8 Proteomics-Based Approaches: New Opportunities in Cancer Research 247
9 Growth Factor Signaling Pathways in Cancer 267
10 Estrogen Action and Breast Cancer 317
11 Cyclin-Dependent Kinases and Their Regulators as Potential Targets for Anticancer Therapeutics 359
12 Angiogenesis Switch Pathways 411
13 Invasion and Metastasis 443
14 Molecular Pathways of Drug Resistance 463
15 Genomic Instability, DNA Repair Pathways, and Cancer 491
16 Immunotherapy for Human Cancer: Evidence and Obstacles 507
17 Treatment with Monoclonal Antibodies 529
18 Emerging Molecular Therapies: Drugs Interfering with Signal Transduction Pathways 569
19 Treatment of Carcinogenesis
20 Suicide Gene Therapy 675
Glossary 695
Index 705