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Morstyn (Monash University, Australia) presents reviews by oncologists, hematologists, and nephrologists on the use of hematopoietic growth factors (HGFs) to promote platelet recovery and ameliorate the complications of cancer and the side effects of chemotherapy. They explain the molecular basis of the effects of HGFs, consider future potential developments, and examine the use of HGFs in oncology. Among the HGFs discussed are granulocyte colony-simulating factor, erythropoietic factors, thrombopoietic factors, and stem-cell factor. The safety and economic considerations of HGFs are also discussed. The book is of interest to oncologists, hematologists, infectious disease physicians, and molecular biologists.

Table of Contents:

Preface
Contributors
1 Introduction to Hematopoietic Growth Factors: A General Overview 3
2 Animal Models of Hematopoietic Growth Factor Perturbations in Physiology and Pathology 11
3 The Jak/Stat Pathway of Cytokine Signaling 45
4 Small-Molecule and Peptide Agonists: A Literature Review 65
5 Granulocyte Colony-Stimulating Factor 83
6 Erythropoietic Factors: Clinical Pharmacology and Pharmacokinetics 97
7 Thrombopoietin Factors 125
8 Stem Cell Factor and Its Receptor, c-Kit 153
9 Hematopoietic Growth Factors: Preclinical Studies of Myeloid and Immune Reconstitution 185
10 Commentary on the ASCO and ESMO Evidence-Based Clinical Practice Guidelines for the Use of Hematopoietic Colony-Stimulating Factors 211
11 Neutropenia and the Problem of Fever and Infection in Patients With Cancer 219
12 Thrombocytopenia and Platelet Transfusions in Patients With Cancer 235
13 Hematopoietic Growth Factors in Lung Cancer 249
14 Role of Hematopoietic Growth Factors As Adjuncts to the Treatment of Hodgkin's and Non-Hodgkin's Lymphomas 275
15 Use of Granulocyte Growth Factors in Breast Cancer 285
16 Role of Cytokines in the Management of Chronic Lymphocytic Leukemia 311
17 Hematopoietic Growth Factor Therapy for Myelodysplastic Syndromes and Aplastic Anemia 333
18 Use of Hematopoietic Growth Factors in AIDS-Related Malignancies 357
19 The Safety of Hematopoietic Growth Factors 375
20 Long-Term Safety of Filgrastim in Chronic Neutropenias 395
21 Economics of Hematopoietic Growth Factors 409
22 Potential for Hematopoietic Growth Factor Antagonists in Oncology 447
Acronyms and Selected Abbreviations 467
Index 475