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List of principal contributors
Color plates
Preface 1
1 Professional virtues in the clinical care of the fetus as a patient 3
2 The embryonic biophysical profile 9
3 Advanced sonoembryology by transvaginal three-dimensional ultrasound 16
4 The volume and vascularity of the yolk sac 24
5 Clinical importance of evaluation of the intervillous circulation 28
6 Screening procedures during the first trimester of pregnancy 37
7 B-mode and Doppler studies of the abnormal fetus in the first trimester 46
8 Ultrasound screening for congenital heart defects: routine or selective? 52
9 Fetal pyelectasis: definition, significance and outcome 58
10 Ultrasonographic morphological assessment of the umbilical cord 64
11 Diagnosis and management of fetal tumors 70
12 Fetal pulmonary arterial and venous flow velocity waveforms during the second half of pregnancy 76
13 Intrauterine growth restriction and fetal cerebral circulation 81
14 Human fetal venous return evaluation: a reappraisal 86
15 Current perspectives on ultrasonic tissue characterization 93
16 Three-dimensional ultrasonography in prenatal diagnosis 102
17 New insights into understanding fetomaternal tolerance 111
18 An update on chorionic villus sampling 117
19 Prenatal diagnosis of hemoglobinopathies 124
20 Fetal cells in maternal blood: diagnostic aid or disease-causing culprit? 130
21 Issues in multifetal pregnancy reduction 136
22 Antepartum testing of fetal well-being 151
23 Doppler flow studies and fetal heart rate variability 157
24 Fetal behavior: integrity of brain stem apparatus 165
25 The development of the senses 171
26 Fetal hemodynamics and behavioral states 181
27 In utero treatment: state of the art 186
28 Current perspectives on twin-to-twin transfusion syndrome 205
29 Fetomaternal transfusion: state of the art 211
30 Perinatal cytomegalovirus infection 217
31 Laboratory and clinical diagnosis of intrauterine infection of the fetus 223
32 The assessment of fetal lung maturity 229
33 Umbilical cord nucleated red cell count as an index of intrauterine hypoxia 238
34 Modern intrapartum surveillance of the fetus - some problems in its evolution 245
35 New perspectives in fetal surgery: prenatal repair of myelomeningocele 254
36 Discrepancy between gestational age and fetal maturity among ethnic groups 267
37 Intrahepatic cholestasis of pregnancy: physiopathology and fetal outcome 274
38 Perinatal Rh hemolytic disease: screening, treatment and personal experience 279
39 Fetal consequences of maternal inherited hypercoagulable states (thrombophilia) 288
40 Pregnancy outcome and obstetric complications following hysteroscopic metroplasty 294
41 Fetal oxygenation and vasoactive agents 301
42 Fetal effects of maternally administered hypotensive drugs: fact and fiction? 310
43 Management of HIV in pregnancy 317
44 Ethical dimensions of HIV infection in pregnancy 331
45 Maternal death during pregnancy: management and ethical aspects 336
46 Epidemiology of pre-eclampsia in The Netherlands 343
47 Physiopathology of pre-eclampsia and intrauterine growth restriction 347
48 Induction of labor 355
49 Post-term pregnancies: evaluation, management and outcome 362
50 Cerebral palsy in multifetal pregnancies: facts and hypotheses 368
51 Perinatal asphyxia 374
52 Ultrasound screening policies in the newborn period 382
53 Computers and fetal medicine 389
Index 397