Adrenal Glands, Vascular System and Hypertension

Author: Gavin P. Vinson
Published: January 1996
Publisher: Blackwell Publishers
ISBN: 1898099073
Hardcover Book
Number of Pages: 312

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The book contains predominantly black-and-white illustrations, with some color illustrations. A collection of 24 papers from the April 1995 international workshop of the same name as the title, held in Hong Kong. The contributors discuss adrenal and renin angiotensin system including structure-function properties and signaling pathways of the angiotensin AT1 receptor, cardiovasular events from the role of the renin-angiotensin-aldosterone system in blood pressure control and sodium excretion in a normal man to ACTH- and steroid-induced hypertension in humans, as well as covering topics in aldosterone synthesis and secretion, aldosteronism and steroid resistance, and adrenal regulation. . Vinson, G. P. (Queen Mary and Westfield Coll); Anderson, D. C.The contributors represent the specialties of endocrinology, reproductive research, chemical pharmacology, pathology, cell/molecular biology, and genetics. Most are from research institutes, hospitals, and universities in eleven countries, including the U.S., the U.K., France, Australia, and Japan. Institutions prominently represented include National Institute of Child Health and Human Development, Hopital Debrousse, Imperial Coll at St Mary's, Osaka Univ, and Greenslopes Hospital-Brisbane.

Table of Contents
1 Structure-function properties and signaling pathways of the angiotensin AT[subscript 1] receptor 3
2 The adrenal cortex and the renin-angiotensin system of lower vertebrates 23
3 Characterization and regulation of corticotropin and angiotensin-II receptors in human and bovine adrenal cells 37
4 Comparative distribution of angiotensin II receptor subtypes in mammalian adrenal glands 53
5 The role of the renin-angiotensin-aldosterone system in blood pressure control and sodium excretion in normal man 71
6 Glucocorticoid exposure in utero: does it cause cardiovascular disease in the adult? 79
7 Signals evoked by angiotensin II in vascular smooth muscle cells 89
8 Tetrandrine, an antihypertensive drug of Chinese medicinal herb origin with Ca[superscript 2+] antagonistic actions: effects on blood vessels and adrenal glands 103
9 Ouabain, adrenal glands and hypertension 115
10 Cardiomyocytes: transmembrane signaling and ANP secretion in response to angiotensin II and arginine vasopressin 123
11 ACTH- and steroid-induced hypertension in humans 135
12 Interaction of brain angiotensin II and the rostral ventrolateral medulla in the spontaneously hypertensive rat: its contribution to hypertension 149
13 Control of aldosterone secretion 'Towards the molecular idiom' 159
14 Steroid 11[Beta]-hydroxylase/aldosterone synthase and its role in blood pressure regulation 187
15 Intercellular communication and aldosterone biosynthesis 195
16 Glucocorticoid and mineralocorticoid resistance: clinical and molecular aspects 211
17 A clinical study on primary aldosteronism 227
18 The genetics of primary aldosteronism 235
19 Acute effect of captopril on urinary excretion of endothelin in normal Chinese subjects 253
20 The influence of amlodipine on the plasma prorenin-renin profile and aldosterone concentration in patients with hypertension 259
21 Application of long-PCR to the screening and detection of familial hyperaldosteronism type I 267
22 Endocrine control of proto-oncogene expression in adult rat adrenal cortex 275
23 Transgenic models for studying adrenal, ovarian, and testicular cancer 281
24 Local fine tuning by noradrenaline and dopamine of steroid release from glomerulosa cells boosted by ACTH 293
Author index 303
Subject index 305

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