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Table of Contents:

The Role of Genotyping in Pharmacological Therapy 1
Pharmacogenetics and the Treatment of Cardiovascular Disease 25
Genetic Polymorphisms and Cardiovascular Drug Metabolism 39
Genes That Modify Susceptibility to Atherosclerosis: Targets for Drug Action 79
Lipid-Lowering Responses Modified by Genetic Variation 107
The Genetic Basis of Essential Hypertension and Its Implications for Treatment 149
Genetic Predisposition to Cardiac Hypertrophy 177
Genetic Determinants of Susceptibility, Prognosis and Treatment in Heart Failure 203
The Genetics of Cardiac Channelopathies: Implications for Therapeutics 223
Insulin Resistance and Cardiovascular Disease: New Insights from Genetics 243
Genetic Disruption of Nitric Oxide Synthases and Cardiovascular Disease: Lessons from a Candidate Gene 281
Association of Thrombotic Disease with Genetic Polymorphism of Haemostatic Genes: Relevance to Pharmacogenetics 311
The Influence of Genetic Factors on Leukocyte and Endothelial Cell Adhesion Molecules 323
Genetic Regulation of Metalloproteinase Activity: Pathogenic and Therapeutic Implications 341
Current Perspectives on Gene and Cell-Based Therapies for Myocardial Protection, Rescue and Repair 359
Subject Index 405