Endocrine Aspects of Successful Aging: Genes, Hormones and Lifestyles

Author: P. Chanson
Published: January 2004
Publisher: Springer-Verlag New York, LLC
ISBN: 3540405739
Hardcover Book
Number of Pages: 231

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At the beginning of the 20th century, life expectancy at birth in North America and Western Europe was around 50 years of age. Nowadays, women have gained more than 30 years of age and men are trailing closer. However, according to several scientists and sociologists, such as Louis Chauvel, the notion of a "greying society" is not entirely adequate since aging people are physically and socially younger and more active for a longer time. Of course, the other side of the medal is to tackle the challenge of preventing age-associated chronic diseases. In this book the extensive field of research on neuroendocrine aging has been reviewed, including data from molecular biology and on simple organisms as well as on the hormonal substitution strategies in humans. Aging is one of the most complex biological processes determined by the interactions between genetic and environmental factors.

Table of Contents:

Regulation of C. elegans Life Span by Insulin-Like Signaling 1
IGF-1 and Insulin Signaling in the Control of Longevity 19
IGF-1 Receptors in Mammalian Longevity: Less is More 35
IGF-1 Gene Polymorphism and Disease in the Elderly 49
Polymorphisms and Male Ageing 63
Age-Related Changes in the Regulation of the Hypothalamic-Pituitary Adrenal Axis: the Role of Personality Variables 89
Aging White Matter and Cognitive Decline: A Role for Steroids 101
How Do Changes in the GH/IGF-1 Status of the Elderly - Whether Occurring Naturally, Pathologically or Therapeutically Induced -Impact Their Lives? 129
Estrogen and Cognitive Functioning in Women 149
Genetic Polymorphisms and Age-Related Diseases: the Example of Osteoporosis 157
Are Estrogens Protective or Risk Factors in the Brain? Insights Derived from Animal Models 165
Testosterone Supplementation and Aging-Associated Sarcopenia 175
The Long Thread of GFAP in Aging, Steroids, and Synaptic Plasticity 191
Circadian Rhythmicity and Aging: The Molecular Basis of Oscillatory Gene Expression 207
Prediction of Death in the Elderly Men: Endocrine Factors 217
Subject Index 229

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