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Pt. I Normal Tissues 1
1 The Potentional Role of Signaling Proteins in the Acceleration of Repopulating Normal and Malignant Tissues 3
2 Role of Radiation-Induced Signaling Proteins in the Response of Vascular and Connective Tissues 15
3 Pathogenetic Mechanisms of Lung Fibrosis 29
4 Strategies for Modification of the Radiation Response of the Lung 37
5 Mechanisms and Modification of the Radiation Response of Gastrointestinal Organs 49
6 Mechanisms and Modification of the Radiation Response of the Central Nervous System 73
7 Hematopoietic Tissue I: Response Modification by Erythropoietin 89
8 Hematopoietic Tissue II: Role of Colony-Stimulating Factors 103
9 Oral Mucosa: Response Modification by Keratinocyte Growth Factor 113
Pt. II Malignancies 123
10 Role of Growth Factors in Tumor Growth and Progression of Gynecological Tumors 125
11 Growth Factor Expression in Central Nervous System Tumours 139
12 Role of Growth Factors and Biological Response Modifiers in Lung, Head and Neck and Gastrointestinal Tumors 147
13 Role of Signaling Pathway Modification 157
14 Anti-VEGF Strategies in Combination with Radiotherapy 179
15 Role of Epidermal Growth Factor Receptor and Its Inhibition in Radiotherapy 189
16 Enhancement of the Radiation Response with Interleukins and Interferons 205
17 Enhancement of Radiation Response with TNF/TRAIL 227
18 Role of Cyclooxygenase-2 (COX-2) and its Inhibition in Tumor Biology and Radiotherapy 241
19 Ras Signaling and Its Inhibition with Farnesyltransferase Inhibitors: Effects on Radiation Resistance and the Tumor Microenvironment 259
Subject Index 275
List of Contributors 279