Current Topics in Microbiology and Immunology: The Molecular Repertoire of Adenoviruses, Vol. 199

Author: M. Potter
Published: January 1995
Publisher: Springer-Verlag New York, LLC
ISBN: 3540588299
Hardcover Book
Number of Pages: 278

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The book contains predominantly black-and-white illustrations, with some color illustrations. For decades this virus system has served - and continues to serve - to pioneer investigations on the molecular biology, biochemistry and genetics of mammalian cell systems. When it comes to investigating mechanistic details in the regulation of transcription or translation, in DNA replication, recombination or integration, in the biological role of de novo DNA methylation, in the structure and assembly of virus particles, in the adsorption of virus particles to the cell surface, and in ideas of nuclear compartmentalization or intracellular transport, adenovirus research still stands the test of time. In this, the first of the three volumes, an overview of adenovirus research is presented with emphasis on the structure and assembly of adenoviruses, viral infections, and viral gene products. Doerfler, Walter (Univ of Cologne); Bohm, Petra (Univ of Cologne)The contributors represent the specialties of biological sciences, molecular biology, pathology, microbiology, immunology, and virology. Most are from the U.S., the U.K., the Netherlands, Germany, Japan, Sweden, and France. Institutions prominently represented include Northwestern, Albert Einstein Coll of Medicine, Imperial Cancer Research Fund in London, and Univ of Glasgow.

Table of Contents
Modulation of Gene Expression by Adenovirus Transformation 1
Adenovirus E1A: Transcription Regulation and Alteration of Cell Growth Control 25
Regulation of p53-Dependent Apoptosis by E1A and E1B 33
Transcriptional Modulation by the Adenovirus E1A Gene 59
Regulation of Viral and Cellular Gene Expression by E1A Proteins Encoded by the Oncogenic Adenovirus Type 12 81
Transcriptional Regulation of the Adenovirus E1A Gene 113
Functional Domains of Adenovirus E1A Oncogenes Which Control Interactions with Effectors of Cellular Immunity 131
Assessing the Role of E1A in the Differential Oncogenicity of Group A and Group C Human Adenoviruses 149
Regulation of Adenovirus E2 Transcription Unit 177
Model Systems for Studying the Effects of Adenovirus E3 Genes on Virulence In Vivo 195
Molecular Determinants of Adenovirus Tropism 213
Enteric Adenoviruses 229
Adenovirus-Augmented, Receptor-Mediated Gene Delivery and Some Solutions to the Common Toxicity Problems 283
Gene Therapy Using Adenovirus Vectors 297
Subject Index 307

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