HIV and Dementia: Proceedings of the NIMH-Sponsored Conference Pathogenesis of HIV Infection of the Brain: Impact on Function and Behavior, Vol. 202

Author: M. B. A. Oldstone
Published: September 1995
Publisher: Springer-Verlag New York, LLC
ISBN: 3540591176
Hardcover Book
Number of Pages: 279

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The principal objective of this monograph is to inform scientists and educated lay audience of now well-documented involvement of the nervous system in AIDS and the tremendous opportunities for basic neuroscience research in this evolving area. The book includes papers presented at the conference Pathogenesis of HIV Infection of the Brain: Impact on Function and Behavior organized by the National Institute of Mental Health, NIH, USA. Recent evidence indicates that HIV infection results in the perturbation of the blood-brain barrier potentially facilitating the entry of HIV into the brain parenchyma and directly causing neuronal dysfunction and ultimate death. In addition, recently established models of AIDS in monkeys, cats, and mice faithfully recapitulate aspects of neuropathophysiology of HIV infection in humans thereby providing new opportunities for research in NeuroAIDS. This book summarizes a 1994 symposium on HIV infection and dementia. The book seeks to be a state-of-the- art review of knowledge of how HIV infection produces dementia. This book will appeal primarily to researchers actively investigating dementia in HIV patients. This book features 17 contributions by researchers in three major areas: HIV dementia in humans, animal models of HIV infection, and in vitro studies of HIV infection. Although up-to-date, this book is limited by a lack of editing or any editorial commentary or oversight. It will be useful to a narrow audience of researchers in the field. Oldstone, Michael B.A. (Scripps Research Institute); Vitkovic, Ljubisa (National Institutes of Health)The contributors represent the specialties of psychiatry, neurology, biology, infectious diseases, epidemiology, pathology, cell biology, pharmacology, and immunology. Most are from academic medical centers and research institutions in the U.S. Institutions prominently represented include NIH, UC Davis, UC San Diego, Scripps Research Institute, and Johns Hopkins.

Table of Contents
The Pathogenesis of HIV Infections of the Brain 3
Neurocognitive Disorders in HIV-1 Infection 11
AIDS Dementia Complex and HIV-1 Brain Infection: A Pathogenetic Framework for Treatment and Evaluation 33
Quantitative Neuropathologic Assessment of HIV-1 Encephalitis 55
Penetration of Solutes, Viruses, and Cells Across the Blood-Brain Barrier 63
Cytotoxic T Lymphocytes and HIV-1-Related Neurologic Disorders 79
Distinct HIV-1 env Sequences Are Associated with Neurotropism and Neurovirulence 89
Role for Astrocytosis in HIV-1-Associated Dementia 105
Therapeutic Approaches to HIV Infection Based on Virus Structure and the Host Pathogen Interaction 117
Neurobiology of Simian and Feline Immunodeficiency Virus Infections 135
Selected Models of HIV-Induced Neurological Disease 151
Feline Immunodeficiency Virus as a Model for Study of Lentivirus Infection of the Central Nervous System 167
Transgenic Models to Assess the Neuropathogenic Potential of HIV-1 Proteins and Cytokines 187
Virus Entry and Release in Polarized Epithelial Cells 209
Traffic of Hematogenous Cells Through the Central Nervous System 221
Principles of Cytotoxic T Lymphocyte Induction and Recognition 247
Virus-Neuron-Cytotoxic T Lymphocyte Interactions 261
Subject Index 275

Click to compare book prices for HIV and Dementia: Proceedings of the NIMH-Sponsored Conference Pathogenesis of HIV Infection of the Brain: Impact on Function and Behavior, Vol. 202 HIV and Dementia: Proceedings of the NIMH-Sponsored Conference Pathogenesis of HIV Infection of the Brain: Impact on Function and Behavior, Vol. 202

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