Immunology of Silicones, Vol. 210

Author: Michael Potter
Published: February 1996
Publisher: Springer-Verlag New York, LLC
ISBN: 3540602720
Hardcover Book
Number of Pages: 430

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This volume contains 46 papers on a variety of topics relating to silicones. The chemistry of silicones and the composition of the commonly used silicone breast implants is described. It has been estimated that around 800,000 women in the U.S. have been recipients of silicone breast implants and there is much concern about the biological reaction to materials contained within these implants. Silicones interact with proteins and tissues, usually in a non-specific way. The question of whether silicone implants cause disease was not the subject of this book. It is generally accepted that under special circumstances silicone gels can induce a chronic inflammatory response and act as immunological adjuvants. The main benefit of this volume is the presentation of a balanced perspective of a field that is often clouded by controversy. Potter, Michael, MD (National Institutes of Health); Rose, Noel R., MD, PhD (Johns Hopkins Univ)The contributors represent the specialties of pathology, radiology, rheumatology, allergy, biology, chemistry, genetics, immunology, surgery, and biology. Most are from universities, companies, and medical institutes in the U.S. Institutions prominently represented include Dow Corning Corporation, Univ of Florida, Harvard Univ, UC Davis, Univ of Iowa, Rochester General Hospital, National Cancer Institute, National Health Institutes, Virginia Commonwealth Univ, and Johns Hopkins Univ.

Table of Contents
Silica, Silicon and Silicones ... Unraveling the Mystery 3
Silicone Degradation Reactions 13
Chemical, Physical and Mechanical Analysis of Explanted Breast Implants 25
Silicon and Silicone Levels in Patients with Silicone Implants 39
Detection of Silicone Migration and Biodegration with NMR 49
Serum Silicon Levels are Elevated in Women with Silicone Gel Implants 59
The Development of an ELISA Method for the Detection of "Antibodies" to Silicone 69
The Adsorption of Proteins on a Polydimethylsiloxane Elastomer (PEP) and Their Antigenic Behavior 75
Aspecific Immunoglobin Binding to Hydrophobic Surfaces 85
Cytotoxicity and Membrane Damage in vitro by Inclusion Complexes Between y-cyclodextrin and Siloxanes 93
Induction of Type-II Collagen Arthritis in the DA Rat Using Silicone Gel as Adjuvant 103
The Adjuvancy of Silicones: Dependency on Compartmentalization 113
The Adjuvant Effect of Silicone Gel and Silicone Elastomer Particles in Rats 123
Silicone Gel and Octamethylcyclotetrasiloxane Potentiate Antibody Production to Bovine Serum Albumin in Mice 139
Fibrogenic and Other Biological Effects of Silica 147
Macrophages in Host Defense Mechanisms 159
Structure and Function of Natural Antibodies 167
Antibodies to Cholesterol: Biological Implications of Antibodies to Lipids 181
Silicone-Induced T-cell Proliferation in Mice 189
Silicone-induced Modulation of Natural Killer Cell Activity 199
HLA Typing in Women with and without Silicone Gel-filled Breast Implants 209
T Cell-Mediated Immune Response to Silica in Silicone Breast Implant Patients 227
Immunohistopathology and T-cell Receptor Gene Expression in Capsules Surrounding Silicone Breast Implants 237
Macrophage-Silicone Interactions in Women with Breast Prostheses 245
Microscopic Techniques and Histologic Finding in Silicone Mammary Implant Capsules and Regional Paranodal Tissues 253
Antinuclear Antibodies in Apparently Healthy Women with Breast Implants 265
Silicone Binding Immunoglobulins in Human Sera 269
Autoantibodies in Patients with Silicone Implants 277
Clinical and Laboratory Features of Patients with Scleroderma and Silicone Implants 283
Re-Evaluation of Autoantibodies and Clinical Overview of Silicone-Related Disorders 291
Development of Scleroderma-like Syndrome in Tsk/+ Mice is not Enhanced by Silicone Administration 299
Comparative Epitope Mapping of Antibodies to Collagen in Women with Silicone Breast Implants, Systemic Lupus Erythematosus and Rheumatoid Arthritis 307
The Prevalence of Autoantibodies in Symptomatic and Asymptomatic Patients with Breast Implants and Patients with Fibromyalgia 317
Monocyte/Macrophage Infiltrates in the Salivary Glands of Women with Silicone Breast Implants 323
Novel Anti-Silicone Surface-associated Antigen Antibodies (anti-SSAA(x)) may help Differentiate Symptomatic Patients with Silicone Breast Implants from Patients with Classical Rheumatological Disease 327
Laboratory Studies in Breast Implant Patients: ANA Positivity, Gammaglobulin Levels, and Other Autoantibodies 337
Is the Risk of Multiple Myeloma Increased in Patients with Silicone Implants? 357
Multiple Myeloma in Women with Silicone Breast Implants. Serum Immunoglobulin and Interleukin-6 Studies in Women at Risk 361
Silicone Gel Implants and Monoclonal Gammopathies: Three Cases of Multiple Myeloma and the Prevalence of Multiple Myeloma and Monoclonal Gammopathy of Undetermined Significance 367
Monoclonal Gammopathy of Undetermined Significance 375
The National Cancer Institute Silicone Implant/Multiple Myeloma Registry 385
The Epidemiology of Monoclonal Gammopathy of Unknown Significance: A Review 389
Plasmacytoma Development in Mice Injected with Silicone Gels 397
The Association of Augmentation Mammoplasty with Connective Tissue Disease, Including Systematic Sclerosis (Scleroderma): A Meta-Analysis 411
The Prevalence of Breast Implants Among Women in the United States 419
Epidemiology of Autoimmune and Immunological Diseases in Association with Silicone Implants: Is There an Excess of Clinical Disease or Antibody Response in Population-based or Other "Controlled" Studies? 427

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