Drug Toxicity in Embryonic Development I: Advances in Understanding Mechanisms of Birth Defects: Morphogenesis and Processes at Risk, Vol. 124

Author: Robert J. Kavlock
Published: January 1997
Publisher: Springer-Verlag New York, LLC
ISBN: 3540612599
Hardcover Book
Number of Pages: 610

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This is a new edition of an edited book in the Handbook of Experimental Pharmacology series. In a two-part edition, the first book teaches the reader about issues in developmental biology of higher vertebrates and recent perturbing experiments that elucidate the molecular mechanisms of development. This book complements the second book in the set, which extends the teaching on molecular mechanisms of development and describes how drugs and toxins perturb developmental mechanisms to produce teratogenic effects. The book is aimed at early post-doctoral physicians and post docs, but would be informative for advanced graduate students and those scientists wishing an overview of molecular teratology. The positive features of the book are its fine group of authors, detailed table of contents, accurate references, and instructive diagrams. Although recommended for purchase, this book could use more diagrams and more up-to-date references. Kavlock, Robert J., PhD (U.S. Environmental Protection Agency); Daston, George P., PhD (Proctor and Gamble)The contributors represent the specialties of medical genetics, molecular biology, and toxicology. Most are from universities, research institutes, and pharmaceutical companies in five countries, including the U.K., the U.S., and Germany. Institutions prominently represented include UNC-Chapel Hill, Salk Institute, and Univ of Toronto.

Table of Contents
Ch. 1 Introduction 1
Ch. 2 Cardiac Morphogenesis: Formation and Septation of the Primary Heart Tube 11
Ch. 3 Vertebrate Limb Development 41
Ch. 4 Axial Skeleton 77
Ch. 5 Molecular Mechanisms Regulating the Early Development of the Vertebrate Nervous System 113
Ch. 6 Genetic Control of Kidney Morphogenesis 129
Ch. 7 Palate 183
Ch. 8 Cell Death 211
Ch. 9 Cellular Responses to Stress 245
Ch. 10 Cell-Cell Interactions 277
Ch. 11 Growth Factor Disturbance 301
Ch. 12 Targeted Gene Disruptions as Models of Abnormal Development 325
Ch. 13 Nucleotide Pool Imbalance 341
Ch. 14 Interference with Embryonic Intermediary Metabolism 373
Ch. 15 Alterations in Folate Metabolism as a Possible Mechanism of Embryotoxicity 407
Ch. 16 Prostaglandin Metabolism 433
Ch. 17 Reactive Intermediates 453
Ch. 18 Hypoxia and Altered Redox Status in Embryotoxicity 519
Ch. 19 Altered Embryonic pH 549
Ch. 20 Maternal Physiological Disruption 573
Subject Index 595

Click to compare book prices for Drug Toxicity in Embryonic Development I: Advances in Understanding Mechanisms of Birth Defects: Morphogenesis and Processes at Risk, Vol. 124 Drug Toxicity in Embryonic Development I: Advances in Understanding Mechanisms of Birth Defects: Morphogenesis and Processes at Risk, Vol. 124

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