Drug Toxicity in Embryonic Development II: Advances in Understanding Mechanisms of Birth Defects: Mechanistic Understanding of Human Developmental Toxicans, Vol. 124

Author: Robert J. Kavlock
Published: January 1997
Publisher: Springer-Verlag New York, LLC
ISBN: 3540612610
Hardcover Book
Number of Pages: 485

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This is a new edition of an edited book in the Handbook of Experimental Pharmacology series. In a two-part edition, this second book teaches the reader about abnormal development occurring in embryos exposed to drugs and toxins. This book complements the first volume in detailing the clinical and experimental outcomes of perturbed development caused experimentally. It does not fully succeed in bridging the molecular understanding created in the first book with the clinical and experimental teratogenesis described in the second. The audience is advanced students, postgraduate physicians, postdoctoral students, and investigators in the field desiring a broad update on more recent developments. It has a fine list of authors, instructive figures, and a wonderful table of contents. I recommend this book for purchase. Kavlock, Robert J., PhD (U.S. Environmental Protection Agency); Daston, George P., PhD (Proctor and Gamble)The contributors represent the specialties of toxicology, genetics, antomy/histology, and pathology. Most are from universities, government agencies, and pharmaceutical companies in the U.S., Sweden, Germany, and Australia. Institutions prominently represented include Free Univ-Berlin, USEPA, and Texas A&M.

Table of Contents
Ch. 1 Introduction 1
Ch. 2 Cardiac Morphogenesis: Formation and Septation of the Primary Heart Tube 11
Ch. 3 Vertebrate Limb Development 41
Ch. 4 Axial Skeleton 77
Ch. 5 Molecular Mechanisms Regulating the Early Development of the Vertebrate Nervous System 113
Ch. 6 Genetic Control of Kidney Morphogenesis 129
Ch. 7 Palate 183
Ch. 8 Cell Death 211
Ch. 9 Cellular Responses to Stress 245
Ch. 10 Cell-Cell Interactions 277
Ch. 11 Growth Factor Disturbance 301
Ch. 12 Targeted Gene Disruptions as Models of Abnormal Development 325
Ch. 13 Nucleotide Pool Imbalance 341
Ch. 14 Interference with Embryonic Intermediary Metabolism 373
Ch. 15 Alterations in Folate Metabolism as a Possible Mechanism of Embryotoxicity 407
Ch. 16 Prostaglandin Metabolism 433
Ch. 17 Reactive Intermediates 453
Ch. 18 Hypoxia and Altered Redox Status in Embryotoxicity 519
Ch. 19 Altered Embryonic pH 549
Ch. 20 Maternal Physiological Disruption 573
Subject Index 595

Click to compare book prices for Drug Toxicity in Embryonic Development II: Advances in Understanding Mechanisms of Birth Defects: Mechanistic Understanding of Human Developmental Toxicans, Vol. 124 Drug Toxicity in Embryonic Development II: Advances in Understanding Mechanisms of Birth Defects: Mechanistic Understanding of Human Developmental Toxicans, Vol. 124

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