Current Topics in Microbiology and Immunology: Toxoplasma Gondii, Vol. 219

Author: Uwe Gross
Published: January 1996
Publisher: Springer-Verlag New York, LLC
ISBN: 3540613005
Hardcover Book
Number of Pages: 274

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For years, toxoplasmosis has been known as a disease that mostly affects newborns who have acquired Toxoplasma gondii in utero. This parasite has gained increasing interest, because of immunocompromised patients, such as those suffering from AIDS, who present a high risk of reactivation of chronic toxoplasmosis, which can eventually result in fatal cerebral disease. The objective of this book is to inform scientists, clinicians, and students of our current knowledge of the interaction between Toxoplasma gondii and its animal or human host. Recent progress in the development of in vivo and in vitro models and the advent of genetic manipulation has made research of Toxoplasma gondii an evolving area and a model for other protozoan parasites. The chapters of this volume include recent findings on antigens and genes of Toxoplasma gondii and the parasite's interaction with the hosts's immune response. Using new technologies, investigations on the developmental differentiation of the parasite have become possible and this knowledge will help us to understand the basis of pathogenesis and persistence of intracellular parasites. Finally, advances in molecular biology and identification of drug targets might lead to new concepts in diagnosis and treatment.

Table of Contents:

Genetic Basis of Pathogenicity in Toxoplasmosis 3
DNA Polymorphisms Associated with Murine Virulence of Toxoplasma gondii Identified by RAPD-PCR 17
Biodiversity in Toxoplasma gondii 27
The Major Surface Proteins of Toxoplasma gondii: Structures and Functions 45
Toxoplasma gondii Microneme Proteins: Gene Cloning and Possible Function 55
Role of Secretory Dense Granule Organelles in the Pathogenesis of Toxoplasmosis 59
Serological Recognition of Toxoplasma gondii Cyst Antigens 67
Toxoplasma gondii: Kinetics of Stage-Specific Protein Expression During Tachyzoite-Bradyzoite Conversion in Vitro 76
Bradyzoite-Specific Genes 81
Immunogenetics in Pathogenesis of and Protection Against Toxoplasmosis 95
Cells and Cytokines in Resistance to Toxoplasma gondii 113
Role of Macrophage-Derived Cytokines in the Induction and Regulation of Cell-Mediated Immunity to Toxoplasma gondii 127
Role of Nitric Oxide-Induced Immune Suppression in Toxoplasmosis During Pregnancy and in Infection by a Virulent Strain of Toxoplasma gondii 141
Cytokine Production by Human Cells after Toxoplasma gondii Infection 155
Characterization of Human T Cell Clones Specific for Toxoplasma gondii 165
Toxoplasma Proteins Recognized by Protective T Lymphocytes 175
Immunological Control of Toxoplasma gondii and Appropriate Vaccine Design 183
Detection of IgA anti-P30 (SAG1) Antibodies in Acquired and Congenital Toxoplasmosis 199
AIDS-Associated Cerebral Toxoplasmosis: An Update on Diagnosis and Treatment 209
Co-infection of Toxoplasma gondii with Other Pathogens: Pathogenicity and Chemotherapy in Animal Models 223
Influence of Antimicrobial Agents on Replication and Stage Conversion of Toxoplasma gondii 235
Molecular Genetic Tools for the Identification and Analysis of Drug Targets in Toxoplasma gondii 247
Studies of the Effect of Various Treatments on the Viability of Toxoplasma gondii Tissue Cysts and Oocysts 261
Subject Index 267

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