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Foreword
Preface
CD4 Counts as Surrogate Markers for AIDS
CD4 Counts in Relation to Markers of Immune Activation 1
Normal Control Values for CD4 and CD8 T Lymphocytes and Their Relevance for HIV-1 Infections 18
Applications of CD4 Counts in a Cohort of HIV-1 Seropositive Patients with Haemophilia 32
Biphasic Decline of CD4+ T Cells during Progression to AIDS: Correlates with the Phenotype of HIV-1 Isolate 46
Opportunistic Diseases as Measure of Immunodeficiency in HIV Infection 54
Defects of Lymphocyte Proliferation and Function in HIV-1 Infection
The Use of in vitro T Cell Immune Function to Monitor the Course of HIV Infection 64
Decreased T Cell Proliferation to Pokeweed Mitogen Is a Prognostic Factor in Asymptomatic HIV-Positive Patients 76
Low T-Cell Responsiveness to Activation via CD3/TCR: A Prognostic Marker for AIDS Useful for Monitoring Antiviral Therapy 85
Proliferative Defects of CD4 and CD8 Lymphocytes in HIV-1 Infection 96
Apoptosis as a Mechanism of Cell Death in Peripheral Lymphocytes from HIV-1-Infected Individuals 115
Programmed Death of Both CD4+ and CD8+ Cells in Asymptomatic HIV-1 Infection 127
T Lymphocyte Functional Defects in HIV Infection 135
Inhibition of CD4+ T Lymphocyte Activation by HIV-1 Glycoproteins gp120 and gp160 145
Abnormalities of Interleukin-2 Receptor Chains in HIV-1 Infection 157
Functional Immunopathology of HIV-1 Infection
Activated CD8+ Cells in HIV-Related Diseases 171
The Staging and Prognostic Value of Subset Markers on CD8 Cells in HIV Disease 185
Activated CD45RO, CD8+ T Lymphocytes in HIV-1 Infection 195
Role of CD8+ T Lymphocytes in the Pathogenesis of HIV Infection 211
The Role of Cytotoxic Lymphocytes in HIV Infection 219
A Soluble Inhibitor of Cytotoxic Functions 228
HIV-Specific Antibody-Dependent Cellular Cytotoxicity and Neutralization 235
Viral and Cellular Requirements for HIV-1 Infection in Monocytes 253
Loss of Dendritic Cell Function: A Basis for Immunodeficiency? 265
Cytokines and Immunoregulatory Factors in the Pathogenesis of HIV Infection: TNF-Effects 278
Epilogue: Immunological Monitoring of HIV-1 Infection 288
Subject Index 293