Hemopoietic Growth Factors, Oncogenes and Cytokines in Clinical Hematology: Current Aspects and Future Directions

Author: E. Cacciola
Published: January 1994
ISBN: 3805558422
Hardcover Book
Number of Pages: 306

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Several significant discoveries have been reported over the past few years concerning the role of extracellular factors in the proliferation and differentiation of hemopoietic cells. This volume describes the latest advances in our understanding of the biological events underlying the development of hemopoietic neoplasms. The first part of the book discusses the mechanisms regulating cell proliferation. In this context the cooperation between growth factors/cytokines and oncogenes in the development of hematological neoplasia is surveyed. The second part focuses on the mechanisms leading to malignant transformation. The use of specific hemopoietic growth factors and cytokines in the management of lymphohemopoietic malignancies is summarized in the final part. The book will give hematologists, oncologists and immunologists a timely update on progress in this important field of investigation and on new directions in the therapy of hemopoietic malignancies.

Table of Contents:

Preface
Mechanisms Regulating Cell Proliferation
Relationship between Growth Factors, Oncogenes and Cytokines in the Mechanism of Aberrant Hematopoiesis 1
The Role of Hematopoietic Stromal Cells in the Regulation of Hematopoiesis 22
Proliferation, Differentiation and Programmed Cell Death: An Outline of Their Genetic Control and Disorders in Normal and Leukemic Myelopoiesis 49
Cytokines That Inhibit Tyrosine Kinase Activity: Receptor Structure and Signal Transduction 64
Receptor Signal Transduction and Cytokine Gene Expression in T Lymphocytes 79
Mechanisms Leading to Malignant Cell Transformation
Altered Surface Immunoregulatory Proteins in Myeloid Leukemias 92
Loss of Growth Regulatory Molecules in Leukemia 102
Cell Kinetic, Molecular and Clinical Analysis of Growth Factor Sensitization of Myeloid Leukemia
Regulation of Drug Sensitivity in Cultures of the Blast Stem Cells of Acute Myeloblastic Leukemia 137
Molecular Pathogenesis of Acute Promyelocytic Leukemia 148
Hemopoietic Growth Factors/Cytokines in the Management of Lymphohemopoietic Malignancies
Advances in the Biology and Treatment of Chronic Myelogenous Leukemia 160
The Use of Growth Factor Receptor Inhibitors in Human Neoplasms 178
Myeloid Growth Factors in Cancer Treatment 196
The Use of Hemopoietic Growth Factors in the Treatment of Myelodysplastic Syndromes 204
Clinical Trials of GM-CSF in Acute Leukemias and Myelodysplasia 220
The Use of Hematopoietic Growth Factors in the Treatment of Malignant Lymphomas 236
Preclinical and Clinical Studies of Hematopoietic Growth Factors in the Setting of Marrow Transplantation 252
Mobilization of Peripheral Blood Progenitor Cells by Hematopoietic Growth Factors for Use in High-Dose Chemotherapy 264
Hematopoietic Growth Factors in Bone Marrow Transplantation: Role in Purging, Graft Engineering, Stem Cell Mobilization, and Hematologic Recovery 273
Clinical and Biological Aspects of Human Umbilical Cord Blood Transplantation for Disease 284
Subject Index 299

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