Endocrine Tumors of the Pancreas

Author: R. Arnold
Published: December 1994
Publisher: Karger, S. Inc.
ISBN: 3805559534
Hardcover Book
Number of Pages: 115

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Endocrine tumors of the pancreas have many special features that distinguish them from other gastrointestinal tumors. The last few years have witnessed numerous advances in areas related to these tumor syndromes ranging from an increased understanding of the pathogenetic and developmental aspects to new methods for localizing these tumors and controlling the hormonal excess state. This ambitious volume not only reviews the various syndromes and tumors, but also presents the latest advances in research and management. It exhaustively updates the knowledge necessary to develop appropriate strategies for the diagnosis and treatment of patients with endocrine tumors of the pancreas. With contributions from leading authorities in their respective areas, the book is an essential reference for hepatogastroenterologists, endocrinologists, oncologists, and surgeons concerned with the alimentary tract and pancreas.

Table of Contents:

Foreword
Preface
Origin of the Parenchymal Cells of the Endocrine Pancreas: Some Phylogenetic and Ontogenetic Aspects 2
Trophic Action of Gastrin on Specific Target Cells in the Gut 30
Analysis of Cell Proliferation and Tumor Antigens of Prognostic Significance in Pancreatic Endocrine Tumors 45
Genetics of Multiple Endocrine Neoplasia Type 1 60
Experimental Models of Endocrine Tumors of the Pancreas 70
Prohormone Processing and Pancreatic Endocrine Tumors 84
Histopathology and Immunopathology of Pancreatic Endocrine Tumors 99
Tumor Markers for Pancreatic Endocrine Tumors, including Chromogranins, HCG-alpha and HCG-beta 121
Expression of Growth Factor Peptides and Adhesion Molecules in Endocrine Pancreatic Tumors 132
Insulinomas: Clinical Presentation, Diagnosis, and Advances in Management 148
VIPomas and Endocrine Cholera: Clinical Presentation, Diagnosis, and Advances in Management 166
Glucagonomas: Clinical Presentation, Diagnosis, and Advances in Management 183
GRFomas, Somatostatinomas: Clinical Presentation, Diagnosis, and Advances in Management 194
PPomas and Nonfunctioning Endocrine Pancreatic Tumors: Clinical Presentation, Diagnosis, and Advances in Management 208
Clinical Features and Advances in Biological Diagnostic Criteria for Zollinger-Ellison Syndrome 223
Advances in Gastric Antisecretory Therapy in Zollinger-Ellison Syndrome 240
Endocrine Tumors of the Pancreatic Area: Localization by Endoscopic Ultrasonography 258
Imaging for Pancreatic Endocrine Tumor Localization: Recent Advances 268
Functional Localization of Pancreatic Endocrine Tumors 282
Use of Radiolabeled Somatostatin to Localize Islet Cell Tumors 298
Surgical Treatment of Islet Cell Tumors with Special Emphasis on Operative Ultrasound 309
Treatment of Gastrinomas with Pancreatoduodenectomy 333
Management of Islet Cell Tumors in Patients with Multiple Endocrine Neoplasia Type 1 342
Clinical Course of Nonsurgically Treated Zollinger-Ellison Syndrome 360
Morphology of Gastric Mucosa during Prolonged Hypergastrinemia 372
Somatostatin Analogues in the Management of Endocrine Tumors of the Pancreas 385
Cytoreductive Hepatic Surgery for Metastatic Gastrointestinal Neuroendocrine Tumors 416
Systemic Chemotherapy for Endocrine Tumors of the Pancreas: Recent Advances 431
Vascular Occlusive Therapy of Pancreatic Endocrine Tumors Metastatic to the Liver 439
Interferon Therapy of Malignant Endocrine Pancreatic Tumors 451
Role of Liver Surgery and Transplantation in Patients with Hepatic Metastases from Pancreatic Endocrine Tumors 461
Subject Index 477

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