Exogenous Dermatology: Advances in Skin-Related Allergology, Bioengineering, Pharmacology, and Toxicology

Author: A. J. Bircher
Published: July 1995
Publisher: Karger, S. Inc.
ISBN: 3805560621
Hardcover Book
Number of Pages: 242

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This concise collection of contributions brings together researchers from many areas of dermatology, including allergology, bioengineering and pharmacology, in commemoration of the 65th birthday of Howard I. Maibach. It reflects only a small number of the fields where Professor Maibach has made a lasting impression. Highlights of this volume include a study on an allergen bank and the ideas behind it, a comprehensive presentation of textile dye contact allergens, and the clinical standardization of the TRUE Test formaldehyde patch. Contributions in bioengineering and occupational dermatology deal with quantification of biophysical properties of the skin, irritancy exposure assessment in metal workers, and the effects of surfactants on skin hydration. A large section on skin pharmacology provides the reader with solid research data and incisive commentaries from researchers and leading authorities on issues of in vitro and in vivo percutaneous absorption, skin metabolism, topical bioavailability and bioequivalency. Dermatologists, pharmacologists and toxicologists will have much to gain from having a copy of this volume close at hand.

Table of Contents:

Preface
Laudatio for Howard I. Maibach
Tribute to Howard I. Maibach
Lessons That Influence the World Entire
The Allergen Bank: The Idea Behind It and the Preliminary Results with It 1
Textile Dye Contact Allergens 8
Immediate Contact Reactions 17
Clinical Standardization of the TRUE Test Formaldehyde Patch
Lymphocyte Transformation Test in the Diagnosis of Immediate Type Hypersensitivity Reactions to Penicillins 31
Contact Allergy: Animal Models 38
UV-Dependent Local Lymph Node Reactions: Photoallergy and Phototoxicity Testing 44
Immunomodulation of Contact Dermatitis 51
Quantification of Biophysical Properties of the Skin 54
Regional Variations of Human Skin Blood Flow Response to Histamine 59
Irritancy Exposure Assessment in Metal Workers 67
Effects of Surfactants on Skin Hydration 72
Occupational Skin Disease 80
Acute Irritant Dermatitis: Effect of Short-Term Topical Corticoid Treatment 86
Antibiotic Resistance in Acne Patients under Antibiotic Treatment in Comparison to an Untreated Control Group with Retrospective Assessment of Therapy 91
Perioral Dermatitis 98
Scabies: What's New? 105
Twenty Absorbing Years 112
Four Decades of Topical Corticosteroid Assessment 124
Percutaneous Absorption: Physical Chemistry Meets the Skin 132
Correlation of in vivo and in vitro Percutaneous Absorption with a Mathematical Model 139
Prediction of Drug Concentration in Blood after Topical Application 146
Challenges in Evaluating Bioequivalence of Dermatological Drug Products 152
Adsorption Columns in in vitro Percutaneous Absorption Studies: A Novel Approach for Dermatopharmacokinetics 158
Polar Pathway for Percutaneous Absorption 164
Effects of Multilamellar Vesicles on the Disruption of Stratum corneum Lipids Barrier in Hairless Mice 171
Transdermal Iontophoresis: Effect of Penetration Enhancer and Iontophoresis on Drug Transport and Surface Characteristics of Human Epidermis 179
Facilitated Drug Delivery during Transdermal Iontophoresis 184
Assessment of Delipidization as an Enhancing Factor in Percutaneous Penetration 189
Percutaneous Absorption of a Drug into Hair Follicles 195
Cutaneous Metabolism and Penetration of Methoxypsoralen, Betamethasone 17-Valerate, Retinoic Acid, Nitroglycerin and Theophylline 201
Examples of the Use of Cell Cultures in Skin Irritancy Assessment 214
In vitro Skin Irritancy: Application of Keratinocytes Cell Culture and Its Correlation with Human Patch Test Responses 231
Subject Index 237

Click to compare book prices for Exogenous Dermatology: Advances in Skin-Related Allergology, Bioengineering, Pharmacology, and Toxicology Exogenous Dermatology: Advances in Skin-Related Allergology, Bioengineering, Pharmacology, and Toxicology

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