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Table of Contents:

Preface
Mechanisms of Skin Irritation 1
Papular and Follicular Contact Dermatitis: Irritation and/or Allergy? 9
What Can We Learn from Epidemiological Studies on Irritant Contact Dermatitis? 18
Statistics on Occupational Dermatoses in Finland 28
Irritant Contact Dermatitis of the Hands in Housewives 41
Occupational Dermatitis in Hairdressing Apprentices. Early-Onset Irritant Skin Damage 49
Expression of Atopic Criteria in a Population of Medical Nurses and Hairdressers at the Beginning of Vocational Training 56
Identification of High-Risk Groups for Irritant Contact Dermatitis by Occupational Physicians 64
The Long-Term Prognosis in Irritant Contact Hand Dermatitis 73
Metalworking Fluid Dermatitis: A Comparative Follow-Up-Study in Patients with Irritant and Non-Irritant Hand Dermatitis 77
The Occlusive Effects of Protective Gloves on the Barrier Properties of the Stratum corneum 87
Human Barrier Formation and Reaction to Irritation 95
Physiologic Response to Chronically Inflamed and Accommodated Human Skin 104
An Immunohistochemical Study of Contact Irritant and Contact Allergic Patch Tests 108
Modulation of Integrins on Epidermal Keratinocytes in vivo and on in vitro Reconstructed Epidermis 114
Human in vivo Microdialysis Technique Can Be Used to Measure Cytokines in Contact Reactions 121
The Spectrum of Irritancy and Application of Bioengineering Techniques 131
Irritant Dermatitis: Experimental Aspects 144
Transepidermal Water Loss Measurements in Patch Test Assessment: The Need for Standardisation 152
Laser Doppler Image Scanning for Assessment of Skin Irritation 159
Image Processing of 20 MHz B-Scan Recordings of Irritant Reactions 169
Horny Layer Thickness as Assessed Functionally Does Not Predict Sodium Lauryl Sulphate Skin Irritation 176
Occlusion Does Not Influence the Repair of the Permeability Barrier in Human Skin 180
Efficacy of Barrier Creams 187
Effect of N-Acetylcysteine, an Inhibitor of Tumor Necrosis Factor, on Irritant Contact Dermatitis in the Human 198
Topical Corticosteroids: Experience with Mometasone Furoate 207
Quantitative Structure-Activity Relationship and Cytotoxicity 224
Measurement of Proinflammatory Mediator Production by Cultured Keratinocytes 230
Transcutaneous Electrical Resistance: Application in Predicting Skin Corrosives 243
EEC/COLIPA in vitro Photoirritancy Program: Results of the First Stage of Validation
Validation of Alternative Tests in the European Union 265
Irritant Reactions on Hairless Micropig Skin: A Model for Testing Barrier Creams? 275
Objective and Reproducible Assessment of Irritants in vivo. A Reappraisal of the IT[subscript 50] in Honour of Kligman and Wooding 288
Subject Index 296