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Table of Contents:

Preface
Predictors of and Therapeutic Strategies in Progressive Chronic Renal Disease 1
Mechanisms and Implications of Heterogeneity of Human Glomerulosclerosis 6
Involvement of Synthesis and Degradation Pathways of Collagen Type IV in Human Glomerulosclerosis: Molecular Analysis by in situ Reverse Transcription and Competitive Polymerase Chain Reaction 12
Lipids and Progressive Renal Failure 17
Cisplatin-Induced Apoptosis in Mouse Proximal Tubular Cell Line 24
Glomerular Capillary Regeneration and Endothelial Cell Apoptosis in Both Reversible and Progressive Models of Glomerulonephritis 29
Role of Apoptosis in the Progression of Glomerulosclerosis 41
Expression of Apoptosis-Preventing Bcl-2 Protein and -Inducing Fas Antigen in Glomeruli of IgA Nephropathy 48
Glomerular Healing 54
Tumor Necrosis Factor in Glomerular Injury 59
The Role of Basic Fibroblast Growth Factor (FGF2) in Glomerular Epithelial Cell Injury 68
TGF-[beta] Behavior in the Progressive Process in the Focal Glomerulosclerosis Rat Model: The Role of Latent TGF-[beta]-Binding Protein 78
Application of Antisense Oligodeoxynucleotides (ODNs) for the Intervention of Kidney Disease. Antisense ODNs for Transforming Growth Factor-[beta]-Suppressed Glomerulosclerosis in Experimental Glomerulonephritis
Gene Transfer of Macrophage Growth Factors into the Kidney of Ipr Mice Initiates Renal Injury 94
Local Macrophage Proliferation in Progressive Renal Injury 100
CD8[superscript +] Lymphocytes Play a Central Role in the Development of Anti-GBM Nephritis through Induction of ICAM-1 and Chemokines in WKY Rats 109
Lipoxygenases as Therapeutic Targets in the Acute and Subacute Phases of Glomerular Immune Injury 113
Abnormalities in Extracellular Matrix Regulation in Autosomal Dominant Polycystic Kidney Disease 126
Activation of Metalloproteinase-2 by Membrane Type Matelloproteinase Expressed on Human Mesangial Cell Membrane 135
Advanced Glycosylation End Products Modulate Transcriptional Regulations on Mesangial Cells 141
Possible Mechanisms of Renal Fibrosis 147
Effect of a Specific Endothelin Receptor A Antagonist on Murine Lupus Nephritis and IgA Nephropathy 155
Proteins Abnormally Filtered Throughout Glomerular Capillary Have an Intrinsic Renal Toxicity 164
Proteinuria: A Mediator of Interstitial Fibrosis? 173
Role of Protein Kinase C in Glucose- and Angiotensin H-Induced Plasminogen Activator Inhibitor Expression 180
The Use of Neutralizing Antibodies to Demonstrate the Role of Transforming Growth Factor-[beta] and Amadori-Glycated Albumin as Mediators of Experimental Diabetic Kidney Disease 188
The Structure of Glomeruli and Juxtaglomerular Arterioles in the Early Phase of Diabetic Nephropathy - Relationship between Progression and Metabolic Control 195
Angiotensin-Converting Enzyme Inhibition in Type I Diabetic Nephropathy 206
Autocrine Secretion of Angiotensin II Mediates Stretch-Induced Hypertrophy of Cardiac Myocytes in vitro 214
Alteration of Cellular Function in Rat Mesangial Cells in Response to Mechanical Stretch Relaxation 222
Glomerular Hypertension and Progressive Renal Disease: The Interplay of Mesangial Cell Stretch, Cytokine Formation and Extracellular Matrix Synthesis 229
Evidence for the Role of Angiotensin in the Establishment and Maintenance of Renal Morphology 234
Modulation of Renin Release and Renal Vascular Smooth Muscle Cell Contractility by TGF-[beta][subscript 2] 238
Role of Angiotensin-Converting Enzyme Gene Polymorphism in Progressive Loss of Renal Function in Chronic Renal Diseases 249
Novel Strategy of Gene Therapy in Cardiovascular Disease with HVJ-Liposome Method 254
Subject Index 265