Prevention of Contact Dermatitis

Author: Howard I. Maibach
Published: August 1996
Publisher: Karger, S. Inc.
ISBN: 3805563116
Hardcover Book
Number of Pages: 226

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This is the first book to extensively cover all aspects of both irritant and allergic contact dermatitis prevention. Edited by a panel of renowned international experts in occupational and environmental dermatitis, it examines the epidemiological basis of the disease, prediction of irritancy and allergenicity by modern techniques, and prevention of percutaneous penetration. Several contributions focus on the practical aspects of preventing allergic and irritant dermatitis in the workplace and, in order to optimize preventive strategies, a number of key chapters detail exposure assessment and the targeting of risk groups. Secondary prevention is also thoroughly discussed with valuable advice on how to avoid recurrences of the disease in patients with a history of contact dermatitis. Finally, up-to-date information and recommendations on protective gloves and skin care products are given by leading researchers in the field. This publication will be of immense interest to dermatologists, occupational physicians, safety engineers, pharmacologists, toxicologists and cosmetologists.

Table of Contents:

Preface
Epidemiological Studies on the Prevention of Occupational Contact Dermatitis 1
Relative and Attributable Risk and Its Relevance to the Prevention of Contact Dermatitis 10
QSAR Predictive of Contact Allergy: Scope and Limitations 18
In vitro Sensitization of Human T Cells with Hapten-Treated Langerhans Cells: A Screening Test for the Identification of Contact Allergens 28
Cutaneous Microdialysis for the Measurement in vivo of the Percutaneous Absorption of Organic Solvents 37
Influence of Evaporation and Repeated Exposure on the Percutaneous Absorption of Organic Solvents 47
Prevention of Contact Dermatitis from Solvents 57
An Immunohistochemical Study on Mild Skin Irritation Induced by a Single Application of a Low-Molarity Sodium Dodecyl Sulfate Solution: Keys to the Prevention of Irritant Contact Dermatitis 67
Prevention of Surfactant-Induced Irritant Contact Dermatitis 78
Allergy Caused by Acrylics: Past, Present and Prevention 86
Prevention by Exposure Assessment 97
Predictive Testing of Metalworking Fluids and Development of Contact Dermatitis in Metalworkers 106
Prevention of Hand Eczema in Atopics 116
Risk-Group-Related Prevention of Hand Eczema at the Workplace 123
Risk Assessment and Exposure Control in an Occupational Setting 133
Secondary Prevention: Detection of the Allergen 145
Prognosis of Contact Dermatitis following Secondary Preventive Measures 154
Barrier Effect of Gloves against Cytostatic Drugs 163
Rubber Glove Dermatitis: A Significant Occupational Hazard-Prevention 170
European Standards on Protective Gloves 177
Efficacy of Protective Creams and/or Gels 182
Percutaneous Penetration (Dermatopharmacokinetics) in Evaluating Barrier Creams 193
Barrier Recompensation Mechanisms 206
Moisturizers in the Prevention of Contact Dermatitis 214
Author Index 221
Subject Index 222

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