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Preface
Basic Principles of Gene Transfer in Hematopoietic Stem Cells 1
Optimizing Conditions for Gene Transfer into Human Hematopoietic Cells 20
Transfer of the MDR-1 Gene into Hematopoietic Cells 50
Ove Hematopoietic Cell Tolerance to Alkylating Agents 65
Use of Variants of Dihydrofolate Reductase in Gene Transfer to Produce Resistance to Methotrexate and Trimetrexate 82
Augmentation of Methotrexate Resistance with Coexpression of Metabolically Related Genes 95
Protection of Bone Marrow Cells from Toxicity of Chemotherapeutic Agents Targeted toward Thymidylate Synthase by Transfer of Mutant Forms of Human Thymidylate Synthase cDNA 107
Dihydropyrimidine Dehydrogenase and Resistance to 5-Fluorouracil 115
Chemoprotection against Cytosine Nucleoside Analogs Using the Human Cytidine Deaminase Gene 124
In vivo Selection of Hematopoietic Stem Cells Transduced with DHFR-Expressing Retroviral Vectors 143
In vivo Selection of Genetically Modified Bone Marrow Cells 162
Gene Transfer in the Nonmyeloablated Host 172
Author Index 179
Subject Index 180