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Preface
Controversies in Neuro-Oncology - Overview 1
Recent Advances of PET in the Diagnosis of Brain Tumors 9
EPI Functional MRI: A Useful Tool for Preoperative Rolandic Fissure Localization 23
Intraoperative Mapping of Eloquent Brain Areas 28
The Value of Iodine-123-Alpha-Methyl-L-Tyrosine Single-Photon Emission Tomography for the Treatment Planning of Malignant Gliomas 37
Boron Neutron Capture Enhancement of Fast Neutron for Nonremoved Glioblastomas: Rationale of a Clinical Trial 43
Commissioning of a Micro-Multileaf Collimator 51
Commissioning of a Micro-Multileaf Collimator for Conformal Stereotactic Radiosurgery and Radiotherapy 64
Neuronavigation and Magnetic Source Imaging in Brain Tumors 78
The Value of 3D Magnetic Resonance Imaging in the Planning of Neurosurgery 88
Intraoperative Radiotherapy in Brain Tumors 94
The Role of Radiotherapy in the Treatment of Craniopharyngeoma - Indications, Results, Side Effects 100
Craniopharyngeomas, Results in Children and Adolescents Operated through a Transsphenoidal Approach Compared with an Intracranial Approach 114
New Developments and Controversies in the Neuropathology of Malignant Gliomas 123
Current Approaches to Radiation Therapy for Malignant Gliomas 139
Hyperfractionated Reirradiation for Malignant Glioma 150
Outcome and Side Effects in Radiotherapy of Glioblastoma - Conventional Fractionation versus Accelerated Hyperfractionation 158
Conventionally Fractionated Radiotherapy of Glioblastoma multiforme. Results and Analysis of Possible Influencing Factors 166
Chemotherapy in Adult Malignant Glioma 174
Indication for Repeat Surgery of Glioblastoma: Influence of Progress of Disease 192
Comparison of Coplanar and Non-Coplanar Irradiation Techniques for Malignant Glioma: An Analysis of Dose-Volume Histograms 202
Local Control of Gliomas: The Next Best Step - A Good Step? 214
Intra-Arterial Virus and Nonvirus Vector-Mediated Gene Transfer to Experimental Rat Brain Tumors 227
Focal Fractionated Conformal Stereotactic Boost following Conventional Radiotherapy of High-Grade Gliomas: A Randomized Phase III Study. A Joint Study of the EORTC (22972) and the MRC (BR10) 241
MRI Characteristics and Histological Changes in Glioblastoma after Gene Therapy 244
Clinical Application of Laboratory Data on Neurotoxicity 253
Pathophysiological Mechanisms Leading to the Development of Late Radiation-Induced Damage to the Central Nervous System 265
Reirradiation after Radiotherapy of Primary Brain Tumors 276
Effects of High-Dose Radiotherapy to Tumors of the Pituitary on the Optic Chiasm 284
Radiomyelopathy after Conventionally Fractionated and Hyperfractionated Radiotherapy - Experimental Data and Clinical Consequences 293
Dose-Volume Tolerance of the Brainstem after High-Dose Radiotherapy 305
Volume Dependence of Late Effects after Radiotherapy of Invasive Pituitary Adenomas 315
A Status of Radiotherapy for Cerebral Metastases 318
Reirradiation for Recurrent Brain Metastases: An Overview 327
A Prospective Study on Neurosurgical Treatment of Cerebral Metastases 332
Chemotherapy of Brain Metastases 343
Primary CNS Lymphoma: Chemotherapy followed by Radiotherapy or Chemotherapy Alone? A Randomized Multicentric Study 349
Topotecan - A New Treatment Option in the Therapy of Brain Metastases of Lung Cancer 354
Topotecan as a 21-Day Continuous Infusion with Accelerated 3D-Conformal Radiation Therapy for Patients with Glioblastoma 364
Author Index 369
Subject Index 371