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Preface
Basic Functions of the Renin-Angiotensin System
Intrarenal Formation of Angiotensin II 1
Signal Transduction Pathways of Angiotensin II in the Kidney 16
Hemodynamic Effects of Angiotensin II in the Kidney 34
Angiotensin II as a Mediator of Renal Tubular Transport 47
Angiotensin IV and Renal Diseases 63
Transgenic Mice as a Tool to Study the Renin-Angiotensin System 72
Angiotensin II in Renal Growth and Development
Angiotensin II as a Renal Growth Factor 92
Guarding the Kidney Architecture: Newly Recognized Physiological Role of Angiotensin 111
Proinflammatory Actions of Angiotensin II
Renin-Angiotensin System and Renal Damage: Emerging Data on Angiotensin II as a Proinflammatory Mediator 123
Angiotensin-Induced Inflammation and Vascular Injury 138
Angiotensin II and Renal Fibrosis
Angiotensin II, TGF-[beta] and Renal Fibrosis 153
Angiotensin as Inducer of Plasminogen Activator Inhibitor-1 and Fibrosis 161
Angiotensin and Renal Fibrosis 171
Renin-Angiotensin System, Proteinuria, and Tubulointerstitial Damage 187
The Renin-Angiotensin System and Specific Diseases
Angiotensin-Converting Enzyme Inhibitors and Progression of Renal Disease: Evidence from Clinical Studies 200
The Renin-Angiotensin System in Diabetic Nephropathy 212
Renin-Angiotensin System in Chronic Renal Allograft Dysfunction 222
Angiotensin II and Atherosclerosis: Relevance for Renal Disease 235
Role of Angiotensin II in Chronic Ureteral Obstruction 250
Author Index 261
Subject Index 262