Peptides and Non Peptides of Oncology and Neuroendocrine Relevance: From Basic to Clinical Research

Author: Eugenio E. E. Muller
Published: July 2003
ISBN: 8847002958
Hardcover Book
Number of Pages: 196

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Hypothalamic regulatory hormones synthesized in the brain, including somatostatin and other peptide and non-peptide molecules, increase the hope for a targeted antineoplastic chemotherapy that only targets tumor cells. Müller (pharmacology, U. of Milan, Italy) presents 17 chapters examining aspects of this new approach, including diagnostic and therapeutic uses of endocrine-derived compounds.

Table of Contents:

Ch. 1 Twenty-five Years of Endocrine Oncology with Analogs of Hypothalamic Peptides: an Overview 3
Ch. 2 Analogs of Luteinizing Hormone-releasing Hormone in Benign Prostatic Hyperplasia and Advanced Renal Cell Carcinoma 21
Ch. 3 Luteinizing Hormone-releasing Hormone Antagonists in Gynecology 29
Ch. 4 Physiology and Pharmacology of Somatostatin and Its Receptors 39
Ch. 5 Investigation of LHRH Receptor Involvement in Melanoma Growth and Progression 47
Ch. 6 Cortistatin: Not Simply a Natural Somatostatin Analogue 57
Ch. 7 Antineoplastic and Antiangiogenic Actions of Somatostatin Analogs 65
Ch. 8 Somatostatin in Clinical Endocrinology 73
Ch. 9 Antagonists of Growth Hormone-releasing Hormone in Oncology 83
Ch. 10 GH Receptor Antagonists: Basic Knowledge and Clinical Perspectives 99
Ch. 11 Hypothalamic Circuits Responsive to Ghrelin: Regulation by Leptin and Insulin 109
Ch. 12 Physiological Function of Growth Hormone Secretagogue Receptors in the Cardiovascular System 117
Ch. 13 Endocrine and Extraendocrine Activity of Ghrelin and the GHS: Basic Research
Ch. 14 Endocrine and Nonendocrine Actions of Ghrelin and GHS: State of the Art in Clinical Research
Ch. 15 Hormonal Treatments of Endocrine-Dependent Tumors: Preclinical Aspects 161
Ch. 16 Hormonal Treatment of Endocrine-Dependent Tumors: Clinical Considerations 169
Ch. 17 Letrozole in the Treatment of Advanced Breast Cancer 183
Subject Index 193

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