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Table of Contents:

Introduction
Contributors
Pt. I Overview
1 Aging and Cancer 1
2 Essentials of Clinical Decision Analysis: A New Way to Think about Cancer and Aging 7
Pt. II Epidemiology
3 International Perspective of Cancer and Aging 19
4 Cancer in Older Persons. Magnitude of the Problem - How do we apply what we know? 95
5 Epidemiology Research in Aging: Perspectives and Limitations 105
6 Factors Affecting the Diagnosis and Treatment of Older Persons with Cancer 115
Pt. III Biology of Aging and Cancer
7 Cellular and Molecular Aging 123
8 Age as a Risk Factor in Multistage Carcinogenesis 157
9 Growth Factors, Oncogenes and Aging 179
10 Biologic Characteristics of Primary Breast Cancer in the Elderly 197
11 Tumor-host Interactions, Aging and Tumor Growth 201
12 Immunological Changes of Aging 213
13 Clinical Evidence for Changes in Tumor Aggressiveness with Age 223
14 Morbid Anatomy of Aging 229
15 Apoptosis, Chemotherapy and Aging 237
Pt. IV The Influence of Aging on Prevention, Diagnosis and Treatment of Cancer
16 Physiology of Aging: Relevance to Symptoms, Perceptions and Treatment Tolerance 247
17 Practical Proposals for Clinical Protocols in Elderly Patients with Cancer 263
18 Quality of Life Considerations in the Older Cancer Patient 271
19 Social Support and the Elderly Cancer Patient 281
20 Prognostic Evaluation of the Older Cancer Patient 287
Pt. V Cancer Prevention in the Aged
21 Nutrition, Cancer and Aging 301
22 Chemoprevention of Cancer in the Elderly 307
23 A Practical Approach to the Screening of Asymptomatic Older Persons for Cancer 325
24 Cancer Screening in the Older Person 333
25 Barriers to Cancer Prevention in the Older Person 351
Pt. VI Management of Cancer in the Older Person
26 Management of Cancer in the Older Person 363
27 Surgical Approaches to the Older Person with Cancer 369
28 Advances in Geriatric Surgery 377
29 Perioperative Considerations in the Geriatric Oncology Patient 387
30 Hemopoiesis and Aging 399
31 The Aging Bone Marrow 413
32 Radiotherapy in the Elderly 421
33 Cancer Chemotherapy in the Older Patient 429
34 New Antineoplastic Agents of Interest to the Older Patient 443
35 Bone Marrow Transplantation in the Older Patient 471
36 Strategies to Prevent Chemotherapy Related Toxicity in the Older Person 481
37 The Role of Endoscopy in the Management of Gastrointestinal Cancers 501
38 Polypharmacy in the Older Patient 525
39 The Diagnosis and Treatment of Cancer in the Elderly: Cost Effectiveness Considerations 533
Pt. VII Management of Specific Tumors in Older Persons
40 Treatment of Acute Myeloid Leukemia in Older Patients 545
41 Chronic Lymphoid Leukemias 551
42 Hodgkin's Disease 565
43 Non-Hodgkin's Lymphomas 577
44 Multiple Myeloma 595
45 Lung Cancer 611
46 Breast Cancer: An Oncological Perspective - Part 1 629
46 Breast Cancer: A Geriatric Perspective - Part 2 661
47 Cancer of the Large Bowel 665
48 Head and Neck Oncology 673
49 Prostate Cancer in the Elderly 679
50 Transitional Cell Carcinoma of the Bladder 697
51 Brain Tumors 703
52 Gynecologic Cancers 721
Pt. VIII Rehabilitation and Supportive Care
53 Management of Infectious Complications 733
54 Principles of Cancer Nursing 743
55 Cancer Pain in the Elderly 753
56 Nutritional Therapy 765
57 Oncological Rehabilitation 781
58 Assessing Needs and Providing Comfort to Geriatric Cancer Patients and their Families 793
59 Family Caregiving Issues 805
60 The Case for a Geriatric Oncology Program in a Cancer Center 813
Index 825