Antigen Delivery Systems: Immunological and Technological Issues, Vol. 8

Author: Bruno Gander
Published: January 1998
Publisher: Taylor & Francis, Inc.
ISBN: 9057022672
Hardcover Book
Number of Pages: 258

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Incl. importance of delivery systems to the immunogenicity of antigens for intensity of antibody & T cell responses. Antigen Delivery Systems: Immunological and Technological Issues, the eighth volume in the Drug Targeting and Delivery book series, gives an overview and update of recent developments in the field of antigen delivery systems. This book provides information on new trends in vaccine development programs from the standpoints of the World Health Organization (WHO) and industry, and the requirement for various vaccine delivery systems is emphasized. Moreover, essential aspects of antigen presentation and adjuvant effect are covered. Examples of frequently studied antigen delivery systems such as liposomes and nano/microparticles are described. In addition to the aspect of preparation technology, the importance of delivery systems to the immunogenicity of various antigens in terms of intensity and duration of antibody and T cell responses is discussed. Traditional, recombinant and synthetic antigens are considered as well as the two main routes of administration, i.e., parenteral and peroral. This book will be of interest to vaccine manufacturers and research scientists (pharmaceutical scientists, biochemists, immunologists) active in the field of vaccine development. In these 13 compiled papers from 35 contributors from the World Health Organization (WHO), academia, and the pharmaceutical industry, the focus is on the pre- clinical evaluation, immunological, and quality control aspects of state-of-the-art adjuvants and antigen delivery systems and technologies: through liposomes, virosomes, ISCOMs, various nanoparticles, and biodegradable polyester microspheres. Also of interest to researchers is the discussion of the role of WHO, which supports single dosage peroral delivery systems, in the development of controlled release vaccines. .

Table of Contents
Preface to the Series
Preface
Contributors
1 The Development of Controlled Release Vaccines - The Role of the World Health Organization 1
2 Peptide-MHC Complexes Assembled Following Multiple Pathways 15
3 Antigen Sampling and Presentation in Mucosal Tissues 35
4 Delivery Systems: The Long Road to Human Vaccines 47
5 The Choice and Mechanism of Action of Adjuvants 57
6 Liposomes as Systemic and Mucosal Delivery Vehicles 73
7 Virosomes, a New Liposome-like Vaccine Delivery System 101
8 ISCOMs: Materials, Preparation, Antigen Delivery and Immune Response 123
9 Design of Nanoparticles for Vaccine Delivery 139
10 Microencapsulation of Antigens for Parenteral Vaccine Delivery Systems 159
11 Immunological Responses with Biodegradable Polymer Microspheres 191
12 Mucosal Immunization with Antigen-containing Microparticles 207
13 Pre-clinical Evaluation and Quality Control Aspects of Microparticulate Antigen Delivery Systems 227
Index 251

Click to compare book prices for Antigen Delivery Systems: Immunological and Technological Issues, Vol. 8 Antigen Delivery Systems: Immunological and Technological Issues, Vol. 8

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