Cancer Radioimmunotherapy: Present and Future

Author: Pietro Riva
Published: September 1998
Publisher: Taylor & Francis, Inc.
ISBN: 9057023091
Hardcover Book
Number of Pages: 510

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Published more than 20 years after the pioneering work of Koler and Milstein, the first researchers to put monoclonal antibodies at the disposal of physicians, this book represents an update of the investigations devoted to the utilization of these new biological probes, conjugated to suitable radioisotopes, for the treatment of different solid and hematological tumors. Much progress has been made since the original findings of monoclonal antibodies, but several problems have to be resolved before this particular therapeutic approach can be applied extensively. Nevertheless some specific protocols, described in the book, look promising. In particular the results recorded in hematological malignancies, in ovarian cancer, and in brain tumors, show similar results as recorded in most kinds of tumors, either as single modality of treatment or in association with more established regimens. Some chapters discuss basic issues such as the production and engineering of antibodies, as well as t

Table of Contents:

Section A: Radioimmunotherapy in Clinical Oncology: The Point of View of the Medical OncologistTraditional and New Isotopes for Radioimmunotherapy Monoclonal Antibodies in Clinical Applications Biodistribution and Pharmacokinetics of Radiolabelled Antibodies New Approaches to Tumor Targeting New Biological Strategies to Improve Radioimmunodetection / Therapy Effectiveness Radioimmunotherapy Using the Avidin-Biotin Pretargeting Approach Dosimetry in Clinical Radioimmunotherapy: Practical Approaches to Reliable Dose Estimates, Biological Effects in Relation to Absorbed Doses Section B: Radioimmunotherapy of Micrometastases Radioimmunotherapy of Osteosarcoma: Future Prospects Radioimmunotherapy of Medullary Thyroid Cancer with Radiolabelled Monoclonal Antibodies to Carcinoembryonic Antigen (CEA) Radioimmunotherapy of Non-Hodgkin's Lymphoma With Non-Myeloablative Doses of Radiolabelled Monoclonal Antibodies Radioimmunotherapy of Ovarian Cancer Radioi

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